INT249602

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 5.06
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc25a1) mitochondrion (Slc25a1)
Anatomy Link Frequency
forearm 2
wrist 2
MCP 1
HeLa 1
fingers 1
Slc25a1 (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 938 99.36 Very High Very High Very High
ischemia 18 31.96 Quite Low
isoflurane 4 6.80 Low Low
anesthesia 2 5.32 Low Low
headache 14 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 1120 99.36 Very High Very High Very High
Injury 42 46.48 Quite Low
Cv Unclassified Under Development 16 31.96 Quite Low
Disease 28 5.00 Very Low Very Low Very Low
Neuropathic Pain 28 5.00 Very Low Very Low Very Low
Hypesthesia 14 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Nicotine Addiction 14 5.00 Very Low Very Low Very Low
Fatigue 14 5.00 Very Low Very Low Very Low
Headache 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H9C2, 3T3, MCA-205, HeLa and HK-2 cells were incubated with increasing concentrations of CTP-6-CF, washed, fixed and counterstained with DRAQ5, a nuclear stain.
Positive_regulation (increasing) of CTP-6-CF in HK-2
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923200 Disease Relevance 0 Pain Relevance 0
In four participants the CTP was increased to 60 mmHg and in four other participants the CTP was increased to 90 mmHg.
Positive_regulation (increased) of CTP
2) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.62 Pain Relevance 0.41
In particular, supination showed higher CTPs than pronation and MCP flexion increased CTP [28,39,42].
Positive_regulation (increased) of CTP in MCP
3) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.11 Pain Relevance 0.11
In aggregate, these studies suggest that CTS development is associated with elevated CTP.
Positive_regulation (elevated) of CTP associated with carpal tunnel syndrome
4) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.74 Pain Relevance 0.47
In four participants the CTP was increased to 60 mmHg and in four other participants the CTP was increased to 90 mmHg.
Positive_regulation (increased) of CTP
5) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.64 Pain Relevance 0.42
In a third group of 4 participants CTP was increased to 30 mmHg.
Positive_regulation (increased) of CTP
6) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.57 Pain Relevance 0.38
The studies show that CTP is dependent on the position of the forearm, wrist and metacarpophalangeal joint (MCP).
Positive_regulation (dependent) of CTP in forearm
7) Confidence 0.40 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.34 Pain Relevance 0.29
Experiments on the effect of positions of fingers, wrist and forearm comparable to the positions common in computer use have shown that CTP increases but not to levels generally believed to be harmful [39,40,42].
Positive_regulation (increases) of CTP in forearm
8) Confidence 0.37 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.12 Pain Relevance 0.12
However, during actual mouse use one study showed an increase of CTP to potentially harmful levels.
Positive_regulation (increase) of CTP
9) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2569035 Disease Relevance 0.48 Pain Relevance 0.39
However, one study showed an increase of CTP during actual mouse use to levels where possible neurological effects were seen experimentally.
Spec (possible) Positive_regulation (increase) of CTP
10) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.18 Pain Relevance 0.18
CTP increased from 8 (SD 6) mmHg at rest to 18 (SD 13) mmHg after lifting 0.5 kilogram cans for 5 minutes at a rate of 20 cans per minute.
Positive_regulation (increased) of CTP in cans
11) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0 Pain Relevance 0
In an often cited study by Lundborg et al[35], CTP was increased experimentally among 16 human volunteers.
Positive_regulation (increased) of CTP
12) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.67 Pain Relevance 0.44
H9C2, 3T3, MCA-205, HeLa and HK-2 cells were incubated with increasing concentrations of CTP-6-CF, washed, fixed and counterstained with DRAQ5, a nuclear stain.
Positive_regulation (increasing) of CTP-6-CF in HeLa
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923200 Disease Relevance 0 Pain Relevance 0
The studies show that CTP is dependent on the position of the forearm, wrist and metacarpophalangeal joint (MCP).
Positive_regulation (dependent) of CTP in wrist
14) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.34 Pain Relevance 0.29
Experiments on the effect of positions of fingers, wrist and forearm comparable to the positions common in computer use have shown that CTP increases but not to levels generally believed to be harmful [39,40,42].
Positive_regulation (increases) of CTP in wrist
15) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.12 Pain Relevance 0.12
Experiments on the effect of positions of fingers, wrist and forearm comparable to the positions common in computer use have shown that CTP increases but not to levels generally believed to be harmful [39,40,42].
Positive_regulation (increases) of CTP in fingers
16) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.12 Pain Relevance 0.12

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