INT24961

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Context Info
Confidence 0.03
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.56
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Defb22)
Anatomy Link Frequency
cerebrospinal fluid 8
Defb22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
excitatory amino acid 8 100.00 Very High Very High Very High
acular 4 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
lidocaine 2 99.98 Very High Very High Very High
Nerve growth factor 62 99.92 Very High Very High Very High
opiate 1 99.84 Very High Very High Very High
intrathecal 8 99.78 Very High Very High Very High
Arthritis 4 99.66 Very High Very High Very High
Morphine 17 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 4 99.66 Very High Very High Very High
Cv General 2 Under Development 3 99.08 Very High Very High Very High
Hyperalgesia 5 98.68 Very High Very High Very High
Post Operative Pain 3 98.32 Very High Very High Very High
Bordatella Infection 4 97.84 Very High Very High Very High
Spina Bifida 3 97.80 Very High Very High Very High
Intracranial Hypertension 18 96.04 Very High Very High Very High
Cancer 1 96.00 Very High Very High Very High
Injury 2 95.64 Very High Very High Very High
Meningitis 2 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the febrile response in zymosan-induced arthritis, as well as the increase in PGE(2) concentration in the cerebrospinal fluid (CSF), along with the effects of antipyretic drugs on these responses in rats.
Positive_regulation (increase) of cerebrospinal fluid in cerebrospinal fluid associated with cv general 2 under development and arthritis
1) Confidence 0.03 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19244587 Disease Relevance 0.51 Pain Relevance 0.14
Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats.
Positive_regulation (Increased) of cerebrospinal fluid in cerebrospinal fluid associated with neuropeptide and opiate
2) Confidence 0.02 Published 1989 Journal Neurosci. Lett. Section Title Doc Link 2482463 Disease Relevance 0 Pain Relevance 1.28
In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino acids (EAAs) and protein kinase C (PKC) activation.
Positive_regulation (activation) of cerebrospinal fluid in CSF associated with kinase c, bordatella infection, thermal hyperalgesia, excitatory amino acid, morphine and intrathecal
3) Confidence 0.02 Published 2006 Journal Life Sci. Section Abstract Doc Link 16271370 Disease Relevance 0.45 Pain Relevance 1.23
In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino acids (EAAs) and protein kinase C (PKC) activation.
Positive_regulation (increase) of cerebrospinal fluid in CSF associated with kinase c, bordatella infection, thermal hyperalgesia, excitatory amino acid, morphine and intrathecal
4) Confidence 0.02 Published 2006 Journal Life Sci. Section Abstract Doc Link 16271370 Disease Relevance 0.45 Pain Relevance 1.15
Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats.
Positive_regulation (elevates) of cerebrospinal fluid in cerebrospinal fluid associated with lidocaine and intrathecal
5) Confidence 0.02 Published 2008 Journal Br J Anaesth Section Title Doc Link 18716004 Disease Relevance 0 Pain Relevance 0.29
Upregulation of cerebrospinal fluid and peripheral prostaglandin E2 in a rat postoperative pain model.
Positive_regulation (Upregulation) of cerebrospinal fluid in cerebrospinal fluid associated with acular and perioperative pain
6) Confidence 0.01 Published 2006 Journal Anesth. Analg. Section Title Doc Link 16861414 Disease Relevance 0.36 Pain Relevance 0.89
The concentration of NGF in cerebrospinal fluid (CSF) was significantly increased as compared with non-allodynic rats.
Positive_regulation (increased) of cerebrospinal fluid in cerebrospinal fluid associated with nerve growth factor
7) Confidence 0.01 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10832021 Disease Relevance 0.38 Pain Relevance 0.81
Abnormal ventricular accumulation of cerebrospinal fluid (CSF), due to obstruction of flow, inadequate absorption, and/or excessive production, results in elevated intracranial pressure (ICP) and ventricular dilation.
Positive_regulation (accumulation) of cerebrospinal fluid in CSF associated with intracranial hypertension and cva
8) Confidence 0.01 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 1.41 Pain Relevance 0.25

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