INT24962

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 5.81
Pain Relevance 13.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Qrfp) cellular_component (Qrfp)
Anatomy Link Frequency
nerve 3
brain 2
neurite 2
gracile nucleus 2
cerebrospinal fluid 1
Qrfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 114 100.00 Very High Very High Very High
substance P 26 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
Sciatic nerve 7 99.82 Very High Very High Very High
Nerve growth factor 7 99.34 Very High Very High Very High
Eae 4 99.24 Very High Very High Very High
medulla 2 99.24 Very High Very High Very High
dorsal root ganglion 21 98.84 Very High Very High Very High
Spinal nerve ligature 11 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Nervous System Injury 8 99.40 Very High Very High Very High
Injury 6 99.24 Very High Very High Very High
Diabetes Mellitus 4 99.00 Very High Very High Very High
Ganglion Cysts 23 98.40 Very High Very High Very High
INFLAMMATION 8 98.24 Very High Very High Very High
Neuropathic Pain 17 97.48 Very High Very High Very High
Pain 12 97.24 Very High Very High Very High
Obesity 8 95.92 Very High Very High Very High
Inflammatory Pain 1 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the results suggest that the anti-allodynic effect of Neuropeptide FF is mediated indirectly by naloxone-sensitive opioid mechanisms in rats subjected to inflammatory, but not neuropathic pain.
Positive_regulation (mediated) of Neuropeptide FF associated with inflammation, neuropathic pain, narcan, neuropeptide and opioid
1) Confidence 0.50 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068020 Disease Relevance 0.95 Pain Relevance 1.19
This further distinguishes little SAAS from the other SCN neuropeptides.
Neg (little) Positive_regulation (little) of neuropeptide associated with neuropeptide
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.22
This further distinguishes little SAAS from the other SCN neuropeptides.
Positive_regulation (distinguishes) of neuropeptide associated with neuropeptide
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.22
Furthermore, the results suggest that the effects of risperidone on neuropeptide mRNA levels are fully accounted for by its D2 antagonism and that no indication exists for a role of 5-HT2A receptor blockade in this action.
Positive_regulation (accounted) of neuropeptide associated with neuropeptide
4) Confidence 0.30 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.32
These observations are interpreted as an induction--or increased expression--of neuropeptide genes in neuronal perikarya postsynaptic to nerve fibers originating in the midbrain and brain stem.
Positive_regulation (induction) of neuropeptide in midbrain associated with neuropeptide and midbrain
5) Confidence 0.28 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7514485 Disease Relevance 0 Pain Relevance 0.84
Their increase following cold acclimation is matched by a major increase in noradrenergic and neuropeptide Y-, substance P- and calcitonin gene-related peptide-containing nerves.
Positive_regulation (increase) of neuropeptide in nerves associated with neuropeptide, calcitonin gene-related peptide and substance p
6) Confidence 0.18 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9701557 Disease Relevance 0.34 Pain Relevance 0.34
Two weeks after chronic constriction injury of adult rat sciatic nerve, galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities were increased in fibers and cells in the gracile nucleus ipsilateral to injury.
Positive_regulation (increased) of neuropeptide in gracile nucleus associated with eae, injury, neuropeptide, sciatic nerve and calcitonin gene-related peptide
7) Confidence 0.17 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.52 Pain Relevance 0.70
Activation of neuropeptide FF neurons in the brainstem nucleus tractus solitarius following cardiovascular challenge and opiate withdrawal.
Positive_regulation (Activation) of neuropeptide in brainstem nucleus associated with medulla, narcan, neuropeptide, opiate and withdrawal
8) Confidence 0.11 Published 1998 Journal J. Comp. Neurol. Section Title Doc Link 9845244 Disease Relevance 0.50 Pain Relevance 1.17
These observations are interpreted as an induction--or increased expression--of neuropeptide genes in neuronal perikarya postsynaptic to nerve fibers originating in the midbrain and brain stem.
Positive_regulation (induction) of neuropeptide in brain stem associated with neuropeptide and midbrain
9) Confidence 0.10 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7514485 Disease Relevance 0 Pain Relevance 0.84
These results show that partial nerve injury to the sciatic nerve induces increases in the content of galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities in synaptic terminals within the gracile nucleus, which suggests that there may be increased release of these neuropeptides following sensory or spontaneous stimulation of large-diameter primary afferents following partial nerve injury, perhaps one mechanism involved in neuropathic pain.
Spec (partial) Positive_regulation (increases) of neuropeptide in gracile nucleus associated with nervous system injury, neuropathic pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide
10) Confidence 0.07 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.63 Pain Relevance 0.94
Arcuate nucleus neuropeptide Y, but not pro-opiomelanocortin, mRNA expression was elevated by STZ treatment and all vagal manipulations; however, exogenous insulin treatment failed to prevent this, in keeping with their previously documented elevated caloric intake.
Positive_regulation (elevated) of neuropeptide in Arcuate nucleus associated with neuropeptide
11) Confidence 0.06 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18638024 Disease Relevance 0.23 Pain Relevance 0.26
Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats.
Positive_regulation (Increased) of neuropeptide-converting in cerebrospinal fluid associated with neuropeptide and opiate
12) Confidence 0.04 Published 1989 Journal Neurosci. Lett. Section Title Doc Link 2482463 Disease Relevance 0 Pain Relevance 1.25
To characterize the factor(s) mediating the neuropeptide Y-induced increase in neurite outgrowth, we have examined whether antisera to either nerve growth factor or neurotrophin-3 influence the neuropeptide Y-induced increase in neurite outgrowth.
Spec (whether) Positive_regulation (increase) of neuropeptide in nerve associated with nerve growth factor and neuropeptide
13) Confidence 0.03 Published 1998 Journal Neuroscience Section Abstract Doc Link 9692759 Disease Relevance 0.24 Pain Relevance 0.65
This study examines further the neuropeptide Y-induced increase in neurite outgrowth.
Spec (examines) Positive_regulation (increase) of neuropeptide in neurite associated with neuropeptide
14) Confidence 0.03 Published 1998 Journal Neuroscience Section Abstract Doc Link 9692759 Disease Relevance 0.23 Pain Relevance 0.60
Contribution of neurotrophin-3 to the neuropeptide Y-induced increase in neurite outgrowth of rat dorsal root ganglion cells.
Positive_regulation (increase) of neuropeptide in neurite associated with ganglion cysts, dorsal root ganglion and neuropeptide
15) Confidence 0.03 Published 1998 Journal Neuroscience Section Title Doc Link 9692759 Disease Relevance 0.25 Pain Relevance 0.62
The neuropeptide substance P (SP) is found within a subpopulation of nociceptive afferent nerve fibres and has been shown to be upregulated in a variety of sites following peripheral inflammation.
Positive_regulation (upregulated) of neuropeptide in nerve associated with nociception, inflammation, neuropeptide and substance p
16) Confidence 0.02 Published 2000 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11153921 Disease Relevance 0.52 Pain Relevance 0.58
Our results confirm the evolutionary conservation of NPFF, NPAF, and NPSF neuropeptide expression in mammalian brain.
Positive_regulation (conservation) of NPSF neuropeptide in brain associated with neuropeptide
17) Confidence 0.01 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.43 Pain Relevance 0.92
However, the pulsatile character of NPFF secretion in itself suggests a biologic role for neuropeptide FF in humans.
Positive_regulation (role) of neuropeptide associated with neuropeptide
18) Confidence 0.01 Published 1998 Journal Peptides Section Abstract Doc Link 9786165 Disease Relevance 0 Pain Relevance 0.20
Calcium-dependent release of tyrosine in brain elicited by stimulation of neuropeptide receptors.
Positive_regulation (stimulation) of neuropeptide in brain associated with neuropeptide
19) Confidence 0.01 Published 1987 Journal J. Neurochem. Section Title Doc Link 3031217 Disease Relevance 0 Pain Relevance 0.81
We first confirmed, using activating transcription factor 3 and neuropeptide Y immunoreactivity, that virtually all L4 DRG neurons are spared from axotomy in this model.
Positive_regulation (using) of neuropeptide in neurons associated with dorsal root ganglion and neuropeptide
20) Confidence 0.00 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15537893 Disease Relevance 0.98 Pain Relevance 1.27

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