INT249624

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD86, CTLA4) Golgi apparatus (CTLA4) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 2
CD86 (Homo sapiens)
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 73 92.88 High High
rheumatoid arthritis 16 81.12 Quite High
metalloproteinase 1 74.96 Quite High
cytokine 1 73.76 Quite High
methotrexate 21 41.84 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 16 81.12 Quite High
Synovitis 1 75.88 Quite High
Autoimmune Disease 1 61.32 Quite High
Disease 9 56.88 Quite High
Cancer 3 31.92 Quite Low
Necrosis 3 31.36 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
Mycobacterial Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTLA-4 binds to CD80 and CD86 with higher avidity than CD28, thus preventing co-stimulation through this pathway, and is a major down-regulatory signal for T cells.
Negative_regulation (preventing) of CD86 Binding (binds) of CTLA-4 in CD86
1) Confidence 0.47 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2569144 Disease Relevance 0.57 Pain Relevance 0.55

General Comments

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