INT24965

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.26
Pain Relevance 5.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal horn 1
Igkv4-59 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 36 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
Analgesic 12 100.00 Very High Very High Very High
spinal dorsal horn 3 100.00 Very High Very High Very High
intrathecal 18 99.98 Very High Very High Very High
qutenza 6 99.24 Very High Very High Very High
Opioid 2 99.12 Very High Very High Very High
Spinal cord 6 92.88 High High
Endogenous opioid 3 90.08 High High
Disease Link Frequency Relevance Heat
Convulsion 3 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal (IT) injection of KK-3, a leucine-enkephalin analogue with weak, naloxone-reversible analgesic effect, produced behavior consisting of scratching, biting, licking and characteristic convulsion-like symptoms in mice.
Gene_expression (produced) of KK-3 associated with convulsion, analgesic, narcan, enkephalin and intrathecal
1) Confidence 0.33 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2482510 Disease Relevance 0.10 Pain Relevance 0.88
In conclusion, enkephalin analogues with a short methylene chain between the functional groups, KK-1 and KK-2, mainly exert their effect through opioid mu-receptors, while those of longer chain, KK-3 and KK-4, act through kappa-receptors preferentially, and KK-3 is situated in the alternating point of the selectivity for mu- and kappa-receptors.
Gene_expression (act) of KK-3 associated with enkephalin and opioid
2) Confidence 0.33 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559186 Disease Relevance 0 Pain Relevance 0.96
In conclusion, enkephalin analogues with a short methylene chain between the functional groups, KK-1 and KK-2, mainly exert their effect through opioid mu-receptors, while those of longer chain, KK-3 and KK-4, act through kappa-receptors preferentially, and KK-3 is situated in the alternating point of the selectivity for mu- and kappa-receptors.
Gene_expression (act) of KK-4 associated with enkephalin and opioid
3) Confidence 0.33 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559186 Disease Relevance 0 Pain Relevance 0.96
These results suggest that KK-3 acts as a releaser of SP in the spinal dorsal horn, and consequently produces SP-like behavior.
Gene_expression (produces) of KK-3 in dorsal horn associated with spinal dorsal horn and substance p
4) Confidence 0.33 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2482510 Disease Relevance 0.07 Pain Relevance 1.48
Release of substance P by intrathecal KK-3, a newly synthesized Leu-enkephalin derivative.
Gene_expression (synthesized) of KK-3 associated with qutenza, enkephalin, intrathecal and substance p
5) Confidence 0.30 Published 1989 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 2482510 Disease Relevance 0.09 Pain Relevance 1.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox