INT24966

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.89
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
nociceptor 1
Syt17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 17 100.00 Very High Very High Very High
nociceptor 17 99.52 Very High Very High Very High
antagonist 9 98.90 Very High Very High Very High
Calcium channel 2 98.68 Very High Very High Very High
sodium channel 4 97.78 Very High Very High Very High
tetrodotoxin 3 97.32 Very High Very High Very High
Hyperalgesia 5 97.08 Very High Very High Very High
b2 receptor 2 96.80 Very High Very High Very High
Antinociceptive 3 95.60 Very High Very High Very High
Calcitonin gene-related peptide 3 93.72 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 98.84 Very High Very High Very High
Pressure And Volume Under Development 3 98.04 Very High Very High Very High
Fever 2 97.64 Very High Very High Very High
Hyperalgesia 5 97.08 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.52 Very High Very High Very High
INFLAMMATION 3 91.92 High High
Nociception 8 85.08 High High
Pain 16 79.08 Quite High
Neuropathic Pain 2 76.40 Quite High
Diabetes Mellitus 3 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein.
Localization (release) of BK in plasma associated with bradykinin
1) Confidence 0.46 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2482813 Disease Relevance 0.61 Pain Relevance 0.70
The local oedema in the vicinity of the nociceptor is associated with the release of BK from plasma proteins, which increases the excitability of the nerve ending (see below).
Localization (release) of BK in nociceptor associated with nociceptor, cv unclassified under development and bradykinin
2) Confidence 0.24 Published 2001 Journal Schmerz Section Abstract Doc Link 11793144 Disease Relevance 0.98 Pain Relevance 1.79
The scorpion toxin (10(-6)M) enhanced BK secretion in both atria (52%) and kidneys (55%).
Localization (secretion) of BK
3) Confidence 0.19 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.56
To further understand the mechanisms of the scorpion toxin action on NPY release, the effects of icatibant (HOE 140, a selective bradykinin-B2 receptor antagonist), tetrodotoxin (TTX, a sodium channel antagonist) and diltiazem (a calcium channel antagonist), and the effect of the scorpion toxin on bradykinin (BK, a potent vasorelaxant peptide of the kinin group) release were studied in both tissues.
Localization (release) of BK associated with tetrodotoxin, calcium channel, antagonist, sodium channel, b2 receptor and bradykinin
4) Confidence 0.17 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.61
Effects of intrathecal and/or systemic administration of B1R agonist (des-Arg9-BK) and antagonists (SSR240612 and R-715) were measured on neuropathic pain manifestations.
Localization (administration) of des-Arg9-BK
5) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.30 Pain Relevance 0

General Comments

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