INT249664

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD81) mitochondrion (CHCHD2) plasma membrane (CD81)
Anatomy Link Frequency
B-cell 2
CD81 (Homo sapiens)
CHCHD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Sicca syndrome 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 168 100.00 Very High Very High Very High
Infection 50 99.34 Very High Very High Very High
Cryoglobulinemia 292 95.88 Very High Very High Very High
Lymphatic System Cancer 34 95.24 Very High Very High Very High
Syndrome 90 94.80 High High
Ulcers 8 94.56 High High
Hepatitis 20 90.96 High High
Apoptosis 2 85.56 High High
Lymphoproliferative Disease 12 81.92 Quite High
Malignant Neoplastic Disease 12 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another important pathogenetic factor is the interaction between HCV E2 protein and CD81 molecule, a quite ubiquitary tetraspannin present on B-cells surface [78]; the consequence may be the strong and sustained polyclonal stimulation of B-cell compartment (Fig. 6).
CD81 molecule Binding (interaction) of HCV E2 protein in B-cell associated with hepatitis c virus infection
1) Confidence 0.00 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.03 Pain Relevance 0
It is possible to hypothesize that during chronic HCV infection, several factors (including the interaction between HCV E2 protein and CD81 molecule, the high viral variability, and the persistent infection of both hepatic and lymphatic cells) may favor a sustained and strong B-cell activation (Fig. 6).
CD81 molecule Binding (interaction) of HCV E2 protein in B-cell associated with hepatitis c virus infection and infection
2) Confidence 0.00 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.48 Pain Relevance 0

General Comments

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