INT249695

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.12
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD19)
Anatomy Link Frequency
B cell 2
CD19 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 97.96 Very High Very High Very High
Spinal cord 1 63.80 Quite High
Inflammation 17 50.00 Quite Low
Arthritis 28 18.72 Low Low
rheumatoid arthritis 17 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
B-cell Lymphoma 27 99.96 Very High Very High Very High
Depression 2 97.96 Very High Very High Very High
Lymphatic System Cancer 122 97.92 Very High Very High Very High
Follicular Lymphoma 22 96.56 Very High Very High Very High
Chronic Fatigue Syndrome 65 94.28 High High
Viral Infection 1 87.60 High High
Fatigue 22 82.48 Quite High
Death 5 74.88 Quite High
Hematologic Neoplasms 2 72.96 Quite High
Hypersensitivity 3 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings together with our observations of depressed CD19+ gene expression and altered association between up and down-regulated B cell functions would suggest that the function of these cells might be compromised in CFS subjects.
Negative_regulation (depressed) of Gene_expression (expression) of CD19 in B cell associated with chronic fatigue syndrome
1) Confidence 0.26 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.69 Pain Relevance 0.05
In specific experiments, the expression of CD19 and CD20 disappeared almost completely after rotation at 16 to 20 rpm, while slower rotation (8 rpm) could partially prevent this effect (Figure 3a).
Negative_regulation (disappeared) of Gene_expression (expression) of CD19
2) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.14 Pain Relevance 0
Although no specific phenotype was found for MZL, levels of CD19 expression in conjunction with CD11c and CD38 expression can distinguish MZL from CD10 negative FL [76].
Negative_regulation (levels) of Gene_expression (expression) of CD19 associated with b-cell lymphoma and follicular lymphoma
3) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 2.29 Pain Relevance 0.03

General Comments

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