INT2497

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Context Info
Confidence 0.23
First Reported 1979
Last Reported 1990
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.49
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 4
lobe 2
superior cervical ganglion 2
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 32 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
adenocard 3 99.58 Very High Very High Very High
antagonist 9 99.28 Very High Very High Very High
opioid receptor 2 98.40 Very High Very High Very High
Kappa opioid receptor 3 98.04 Very High Very High Very High
agonist 6 97.12 Very High Very High Very High
Dopamine 37 96.80 Very High Very High Very High
tetrodotoxin 4 92.80 High High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 98.96 Very High Very High Very High
Galactorrhea 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of morphine was observed on DOPA accumulation in the median eminence of NSD-treated rats that had received 50 ng of morphine sulfate intracerebroventricularly, and only a 50% reduction was observed in the accumulation of DOPA in the median eminence of rats given 500 ng of morphine sulfate.
Neg (No) Regulation (effect) of Positive_regulation (accumulation) of DOPA in median eminence associated with morphine
1) Confidence 0.23 Published 1983 Journal Brain Res. Section Abstract Doc Link 6404502 Disease Relevance 0 Pain Relevance 1.18
Since the effects of morphine on the apomorphine-induced inhibition of DOPA accumulation were antagonized by naloxone, we suggest that the effects on striatal DOPA accumulation produced by morphine were mediated via opioid receptors and not directly via DA receptors.
Regulation (effects) of Positive_regulation (accumulation) of DOPA associated with narcan, opioid receptor and morphine
2) Confidence 0.11 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.19
Effect of morphine on the accumulation of DOPA after decarboxylase inhibition in the rat.
Regulation (Effect) of Positive_regulation (accumulation) of DOPA associated with narcan and morphine
3) Confidence 0.11 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 456411 Disease Relevance 0 Pain Relevance 1.09
Addition of dibutyryl cAMP (db-cAMP) into medium caused an increase in the rate of DOPA accumulation in the median eminence in a dose- and time-dependent manner. 8-Bromo-cAMP also increased the rate of DOPA accumulation in the median eminence and cAMP was less effective than db-cAMP whereas neither adenosine nor sodium butyrate altered the rate of DOPA accumulation.
Neg (neither) Regulation (altered) of Positive_regulation (accumulation) of DOPA in median eminence associated with adenocard
4) Confidence 0.09 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.33
This difference in DOPA accumulation was due to the changes in PRL secretion after Halo and Bromo treatments, since hypophysectomy abolished it.
Regulation (changes) of Positive_regulation (accumulation) of DOPA
5) Confidence 0.07 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.34
On the other hand, neither Halo nor Bromo treatment altered the increase in DOPA accumulation induced by (Bu)2cAMP or forskolin.
Neg (neither) Regulation (altered) of Positive_regulation (accumulation) of DOPA
6) Confidence 0.07 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.20
We have investigated the effect of veratridine on DOPA (3,4-dihydroxyphenylalanine) accumulation by the superior cervical ganglion of the rat.
Spec (investigated) Regulation (effect) of Spec (investigated) Positive_regulation (accumulation) of DOPA in superior cervical ganglion associated with ganglion cysts
7) Confidence 0.03 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.34 Pain Relevance 0.12
The effects of U-50488 on plasma alpha-MSH concentrations and intermediate-lobe DOPA accumulation were blocked by pretreatment with the selective kappa-opioid receptor antagonist nor-binaltorphimine.
Regulation (effects) of Positive_regulation (accumulation) of DOPA in lobe associated with antagonist and kappa opioid receptor
8) Confidence 0.01 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2177159 Disease Relevance 0 Pain Relevance 0.66

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