INT249718

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.52
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MCF2L) plasma membrane (MCF2L) cytoplasm (MCF2L)
Anatomy Link Frequency
nucleus accumbens 2
neurons 1
ventral 1
MCF2L (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 184 100.00 Very High Very High Very High
cingulotomy 20 98.64 Very High Very High Very High
Nucleus accumbens 18 97.56 Very High Very High Very High
depression 99 96.80 Very High Very High Very High
amygdala 10 87.84 High High
imagery 18 83.80 Quite High
positron emission tomography 3 83.48 Quite High
Thalamus 41 78.40 Quite High
Transcranial magnetic stimulation 83 76.48 Quite High
vagus nerve 24 74.16 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 37 99.44 Very High Very High Very High
Disease 102 98.50 Very High Very High Very High
Movement Disorders 8 97.92 Very High Very High Very High
Depression 207 97.32 Very High Very High Very High
Confusion 5 90.08 High High
Cognitive Disorder 28 87.52 High High
Recurrence 6 70.40 Quite High
Dyskinesias 6 63.64 Quite High
Suicidal Behaviour 3 54.96 Quite High
Hypokinesia 9 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
And we have developed increasingly sophisticated models of the physics of DBS stimulation to help us understand how DBS interacts with neurons.
DBS Binding (interacts) of in neurons associated with deep brain stimulation
1) Confidence 0.16 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.41 Pain Relevance 0.40
Third, the targets have been singled out because the disease of the patient leads to dysfunction of the target which is intended to be normalized by DBS.
DBS Binding (normalized) of associated with deep brain stimulation and disease
2) Confidence 0.15 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2570064 Disease Relevance 0.60 Pain Relevance 0.11
After clinical evaluations, they concluded that the best target for DBS to alleviate OCD symptoms was the ventral caudate, and for the best outcome in depression, the nucleus accumbens was pointed as the best option [3].
DBS Binding (target) of in nucleus accumbens associated with nucleus accumbens, depression, deep brain stimulation and anxiety disorder
3) Confidence 0.15 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2844529 Disease Relevance 0.87 Pain Relevance 0.59
Targets for DBS included the subgenual cingulate cortex (Brodmann area 25), nucleus accumbens, ventral caudate/striatum, inferior thalamic peduncle, globus pallidus internus, and the lateral habenula [5, 51, 64, 72, 73, 100, 101].
DBS Binding (Targets) of in ventral associated with nucleus accumbens and deep brain stimulation
4) Confidence 0.15 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2844529 Disease Relevance 0.54 Pain Relevance 0.50
Predictably, the adverse effects associated with DBS are largely the consequence of surgery as opposed to stimulation.
DBS Binding (associated) of associated with deep brain stimulation
5) Confidence 0.15 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.57 Pain Relevance 0.25
Targets for DBS included the subgenual cingulate cortex (Brodmann area 25), nucleus accumbens, ventral caudate/striatum, inferior thalamic peduncle, globus pallidus internus, and the lateral habenula [5, 51, 64, 72, 73, 100, 101].
DBS Binding (Targets) of in nucleus accumbens associated with nucleus accumbens and deep brain stimulation
6) Confidence 0.05 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2844529 Disease Relevance 0.54 Pain Relevance 0.50

General Comments

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