INT24974

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Context Info
Confidence 0.42
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.68
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocytes 1
stomach 1
urine 1
Naglu (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 1 95.92 Very High Very High Very High
imagery 4 93.76 High High
Arthritis 2 93.52 High High
anesthesia 3 89.88 High High
Central nervous system 1 78.60 Quite High
Pain 5 75.56 Quite High
Antinociceptive 1 75.00 Quite High
Pain threshold 1 62.48 Quite High
Analgesic 2 25.00 Low Low
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Syndrome 5 99.92 Very High Very High Very High
Mucopolysaccharidoses 11 99.20 Very High Very High Very High
Hearing Impairment 1 97.40 Very High Very High Very High
Carpal Tunnel Syndrome 1 95.92 Very High Very High Very High
Arthritis 3 93.52 High High
Obesity 2 93.20 High High
Cleidocranial Dysplasia 1 92.48 High High
Congenital Anomalies 1 87.60 High High
Frailty 2 85.68 High High
Necrosis 2 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lysosomal enzymes (acid phosphatase and N-acetyl glucosaminidase) were decreased by 50% (P < 0.01) and 26.26% (P < 0.05) by using Cissampelos pareira, dextramethasone decreased them 56.56% (P < 0.01) and 31.82% (P < 0.01) and the glycoprotein contents (total hexose and sialic acid) were increased by 1.55-folds (P < 0.01) and 1.51-folds (P < 0.05) by using Cissampelos pareira while dextramethasone increases them by 1.51-folds (P < 0.001) and 1.60-folds (P < 0.01) respectively in stomach homogenate with respect to arthritic group.
Negative_regulation (decreased) of N-acetyl glucosaminidase in stomach associated with arthritis
1) Confidence 0.42 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17240096 Disease Relevance 0.39 Pain Relevance 0.38
Due to marked urinary excretion of heparan sulfate, as well as deficiency of alpha-N-acetylglucosaminidase in leukocytes, the diagnosis of Sanfilippo B syndrome was made.
Negative_regulation (deficiency) of alpha-N-acetylglucosaminidase in leukocytes associated with syndrome
2) Confidence 0.28 Published 2001 Journal Brain Dev. Section Abstract Doc Link 11578848 Disease Relevance 1.25 Pain Relevance 0.30
All enzyme activity is depressed significantly during the 9- to 21-week interval: alpha-glucosidase, beta-glucosidase, alpha-mannosidase, beta-galactosidase, acid phosphatase, N-acetyl-beta-galactosaminidase, 5'-phosphodiesterase type IV, and total rho-nitrophenyl phosphatase are reduced approximately 10 to 20 per cent, whereas beta-glucosaminidase, aryl sulfatase, and N-acetyl-beta-glucosaminidase are decreased almost 40 to 50 per cent.
Negative_regulation (decreased) of beta-glucosaminidase
3) Confidence 0.20 Published 1980 Journal Lab. Invest. Section Abstract Doc Link 7421126 Disease Relevance 0.34 Pain Relevance 0.07
The pathologic changes in a rare case of mucopolysaccharidosis (MPS) type IIIB or Sanfilippo's syndrome B (absence of alpha-N-acetylglucosaminidase) are presented, along with the biochemical findings.
Negative_regulation (absence) of alpha-N-acetylglucosaminidase associated with syndrome and mucopolysaccharidoses
4) Confidence 0.09 Published 1980 Journal Arch. Neurol. Section Abstract Doc Link 6775621 Disease Relevance 0.54 Pain Relevance 0.08
Urinary elimination of N-acetylglucosaminidase and of alanine aminopeptidase was determined in the 24-hour urine the day before surgery (controls), the day of surgery (G1) and the day after surgery (G2).
Negative_regulation (elimination) of N-acetylglucosaminidase in urine
5) Confidence 0.06 Published 1989 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 2483317 Disease Relevance 0.16 Pain Relevance 0.09

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