INT249750

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

nucleus (Nfe2l2, TFAM) DNA binding (Nfe2l2, TFAM) mitochondrion (TFAM) plasma membrane (Nfe2l2) cytoplasm (Nfe2l2)

Nfe2l2 (Mus musculus) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 2 5.00 drug abuse 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Aging 15 62.72 Parkinson's Disease 10 5.00 Lifespan 8 5.00 Insulin Resistance 3 5.00 Diabetes Mellitus 3 5.00 Disorder Of Lipid Metabolism 3 5.00 Metabolic Syndrome 2 5.00 Hyperinsulinism 2 5.00 Rheumatoid Arthritis 2 5.00 Anaemia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TFAM expression is controlled by upstream nuclear transcription factors (NRF1, NRF2), which also regulate the expression of nuclear genes encoding mitochondrial proteins.

NRF2 Regulation (controlled) of Gene_expression (expression) of TFAM

1) Confidence 0.00 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0.06 Pain Relevance 0

General Comments

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