INT24978

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 15.09
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
brain 2
T-cell 2
sacroiliac joint 1
anterior 1
bowel 1
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 114 100.00 Very High Very High Very High
Neuropeptide 3 99.98 Very High Very High Very High
rheumatoid arthritis 69 99.76 Very High Very High Very High
spinal inflammation 315 99.60 Very High Very High Very High
Nerve growth factor 16 99.56 Very High Very High Very High
Catecholamine 8 99.48 Very High Very High Very High
Infliximab 255 98.76 Very High Very High Very High
antagonist 43 98.52 Very High Very High Very High
Acupuncture 10 98.36 Very High Very High Very High
Arthritis 59 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myasthenia Gravis 168 100.00 Very High Very High Very High
Spondylarthropathies 5 100.00 Very High Very High Very High
Uveitis 165 99.98 Very High Very High Very High
Kernicterus 1 99.80 Very High Very High Very High
Rheumatoid Arthritis 76 99.76 Very High Very High Very High
Ankylosing Spondylitis 4 99.72 Very High Very High Very High
Pyoderma Gangrenosum 5 99.62 Very High Very High Very High
Exencephaly /

Neural Tube Defects

1 99.40 Very High Very High Very High
Psoriasis 19 98.90 Very High Very High Very High
Stress 35 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antigen from porcine and human pancreas extracts was partially purified using a monoclonal antibody, SP3-1, which recognizes the antigen in duct cells of various exocrine organs.
SP3-1 Binding (cognizes t) of in duct
1) Confidence 0.47 Published 1994 Journal Pancreas Section Abstract Doc Link 8022761 Disease Relevance 0.72 Pain Relevance 0.40
There is a functional interaction between SP and endorphin in the effects of electro-acupuncture.
SP Binding (interaction) of associated with acupuncture
2) Confidence 0.35 Published 1989 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2483985 Disease Relevance 0.19 Pain Relevance 1.07
First the clinical features associated with SpA were investigated, then the human leucocyte antigen (HLA)-B27 and sacroiliac joint radiographic examinations were carried out.
SpA Binding (associated) of in sacroiliac joint
3) Confidence 0.35 Published 2009 Journal Scand. J. Rheumatol. Section Body Doc Link 19922021 Disease Relevance 0.09 Pain Relevance 0
These 2 cases, together with the recently reported case of PG and B27-positive psoriatic spondylarthropathy, suggest that PG may also occur in association with forms of seronegative SpA that are different from primary ankylosing spondylitis (AS) and AS associated with inflammatory bowel disease.
SpA Binding (association) of in bowel associated with psoriasis, spinal inflammation, inflammation, spondylarthropathies and pyoderma gangrenosum
4) Confidence 0.30 Published 1996 Journal Arthritis Rheum. Section Abstract Doc Link 8651972 Disease Relevance 1.41 Pain Relevance 0.34
For example, a low motor threshold in patient S.Pe. is associated with a lengthened SP whereas in patient M.G. the opposite trend is observed.
SP Binding (associated) of
5) Confidence 0.28 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.09 Pain Relevance 0.30
Damage to different brain areas can also cause a SP prolongation.
SP Binding (prolongation) of in brain
6) Confidence 0.28 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.23 Pain Relevance 0.08
We extend these result by showing that duration of the SP is also modified when interhemispheric interactions have been absent since birth.
SP Binding (duration) of
7) Confidence 0.28 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.21 Pain Relevance 0.10
Furthermore, some of these have been associated with certain SpA, such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA).
SpA Binding (associated) of associated with seronegative spondarthritis, spinal inflammation, ankylosing spondylitis and arthritis
8) Confidence 0.27 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19731638 Disease Relevance 0.56 Pain Relevance 0.43
Our results also indicate a possible role for IL-1 and its receptors in SpA.
SpA Binding (receptors) of
9) Confidence 0.26 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19900269 Disease Relevance 0 Pain Relevance 0
Patients with SpA appear to have Th2 polarization with decreased T-cell production of IFN?
SpA Binding (Patients) of in T-cell
10) Confidence 0.17 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.79 Pain Relevance 0.49
Concerning anterior uveitis associated with SpA, there is some recent evidence from controlled trials that sulfasalazine does prevent attacks [23,27], while the data for methotrexate are less clear.
SpA Binding (associated) of in anterior associated with uveitis and methotrexate
11) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 1.13 Pain Relevance 0.57
In contrast to patients with RA [147,148], those with SpA seem to have an impaired Th1/Th2 balance [149]), with decreased T-cell production of IFN-?
SpA Binding (those) of in T-cell associated with rheumatoid arthritis
12) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 1.30 Pain Relevance 0.68
It was shown that B*2706, probably like B*2709 in Sardinia, is not associated with SpA.
SpA Binding (associated) of
13) Confidence 0.08 Published 2001 Journal Curr Opin Rheumatol Section Abstract Doc Link 11555729 Disease Relevance 0.15 Pain Relevance 0
As stated, AAU has been strongly linked to HLA-B*27 and SpA.
SpA Binding (linked) of associated with uveitis
14) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 1.66 Pain Relevance 0.29
AAU has also been associated with early onset of SpA in HLA-B*27-positive patients [15].
SpA Binding (associated) of associated with uveitis
15) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 1.77 Pain Relevance 0.30
However, it can also be suggested that [Sar9,Met(O2)11] SP and SP on the one hand, and hHK-1 on the other hand, may bind to different sites of the NK1 receptor and interact in a different manner with receptor antagonists [5,56].
SP Binding (interact) of associated with antagonist and substance p
16) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.06 Pain Relevance 0.57
However, it can also be suggested that [Sar9,Met(O2)11] SP and SP on the one hand, and hHK-1 on the other hand, may bind to different sites of the NK1 receptor and interact in a different manner with receptor antagonists [5,56].
SP Binding (interact) of associated with antagonist and substance p
17) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.06 Pain Relevance 0.57
In the presence of Sp4 in the brain, one could speculate that this effect may be magnified, because Sp4 binding to sites I and II is not affected by the loss of Sp binding to site III, and the resulting stimulated LTR may have high levels of both Sp and NF-?
Sp Binding (binding) of in brain
18) Confidence 0.02 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.58 Pain Relevance 0
Core promoter and enhancer regions: the interaction of Sp, NF-?
Sp Binding (interaction) of
19) Confidence 0.02 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.64 Pain Relevance 0
Construct validity of the OHIP-Sp
OHIP-Sp Binding (validity) of
20) Confidence 0.02 Published 2006 Journal BMC Oral Health Section Body Doc Link PMC1534011 Disease Relevance 0.39 Pain Relevance 0.25

General Comments

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