INT249785

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.71
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
basal cell 4
pancreas 2
endocrine cells 2
appendix 2
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 27 92.08 High High
rheumatoid arthritis 65 84.84 Quite High
Inflammation 75 60.08 Quite High
cytokine 15 57.84 Quite High
Arthritis 64 6.24 Low Low
analgesia 9 5.00 Very Low Very Low Very Low
Buprenorphine 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 186 100.00 Very High Very High Very High
Basal Cell Neoplasms 2 99.44 Very High Very High Very High
Papillomavirus Infection 28 99.24 Very High Very High Very High
Targeted Disruption 124 99.14 Very High Very High Very High
Apoptosis 79 97.80 Very High Very High Very High
Skin Cancer 10 96.72 Very High Very High Very High
Cancer 208 96.24 Very High Very High Very High
Impaired Glucose Tolerance 27 92.72 High High
Hyperplasia 32 90.64 High High
Rheumatoid Arthritis 65 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, Foxm1 expression was upregulated twofold in control islets 6 days following PPx versus sham (Fig. 2), suggesting that FoxM1 plays a role in the regenerative response of endocrine cells.
Positive_regulation (upregulated) of Gene_expression (expression) of Foxm1 in endocrine cells
1) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Despite FoxM1 overexpression within islets (online appendix Fig.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FoxM1 in appendix
2) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.35 Pain Relevance 0.05
FOXM1 overexpression did not affect ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of FOXM1
3) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.14 Pain Relevance 0
To determine whether Foxm1 overexpression affects pancreas and ?
Spec (whether) Positive_regulation (overexpression) of Spec (whether) Gene_expression (overexpression) of Foxm1 in pancreas
4) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.30 Pain Relevance 0.04
Foxm1 overexpression did not enhance ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Foxm1
5) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.23 Pain Relevance 0.03
Because FOXM1 overexpression in human keratinocytes has been suggested to contribute to cell transformation leading to the development of basal cell cancer [47], it seems likely that FOXM1 overexpression may contribute to HPV-induced keratinocyte transformation and the development of skin cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FOXM1 in basal cell associated with papillomavirus infection, basal cell neoplasms and skin cancer
6) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.60 Pain Relevance 0
Because FOXM1 overexpression in human keratinocytes has been suggested to contribute to cell transformation leading to the development of basal cell cancer [47], it seems likely that FOXM1 overexpression may contribute to HPV-induced keratinocyte transformation and the development of skin cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FOXM1 in basal cell associated with papillomavirus infection, basal cell neoplasms and skin cancer
7) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.60 Pain Relevance 0
-cell regeneration following PPx, we utilized Rosa26-FoxM1 Tg mice that constitutively and ubiquitously overexpress human FoxM1 (23).
Positive_regulation (overexpress) of Gene_expression (overexpress) of FoxM1 associated with targeted disruption
8) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.35 Pain Relevance 0.04
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Positive_regulation (upregulation) of Gene_expression (targets) of FoxM1
9) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.11 Pain Relevance 0
However, FoxM1?
Positive_regulation (However) of Gene_expression (However) of FoxM1
10) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
However, FoxM1?
Positive_regulation (However) of Gene_expression (However) of FoxM1
11) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.08 Pain Relevance 0
In that regard, overexpression of FoxM1 was shown to specifically override bortezomib-induced-apoptosis, but not doxorubicin-induced cancer cell apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FoxM1 associated with cancer and apoptosis
12) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.18 Pain Relevance 0.19
To validate these TUSC2-dependent transcriptional changes we overexpressed TUSC2 in four additional MPM cell lines and performed RT-PCR evaluation of several potential TUSC2 targets.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MPM associated with lung cancer
13) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.52 Pain Relevance 0
Prominent transcriptional effects triggered by TUSC2 over-expression in MPM suggested that it may function as an essential transcriptional regulator.
Positive_regulation (over) of Gene_expression (expression) of MPM associated with lung cancer
14) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.25 Pain Relevance 0

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