INT249788

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Ccnb1) cytoplasm (Ccnb1) mitosis (Ccnb1)
nucleus (Ccnb1) cytoskeleton (Ccnb1) cell cycle (Ccnb1)
Anatomy Link Frequency
skin 2
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 92.40 High High
Skin Cancer 5 75.00 Quite High
Leukemia 1 74.44 Quite High
Lymphatic System Cancer 1 74.04 Quite High
Injury 6 66.72 Quite High
Hyperglycemia 2 54.40 Quite High
Targeted Disruption 41 50.00 Quite Low
Papillomavirus Infection 14 50.00 Quite Low
Hyperplasia 7 43.60 Quite Low
Cervical Cancer 9 28.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Positive_regulation (upregulation) of Gene_expression (targets) of Ccnb1
1) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0
Thus, it is likely that the inactivation of p53 function by HPV16 E6 oncoprotein might be responsible for cyclin B1 overexpression in skin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin B1 in skin
2) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.39 Pain Relevance 0

General Comments

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