INT2498

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Context Info
Confidence 0.47
First Reported 1979
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mlst8) molecular_function (Mlst8) biological_process (Mlst8)
cytoplasm (Mlst8)
Mlst8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABA receptor 1 100.00 Very High Very High Very High
anticonvulsant 3 98.80 Very High Very High Very High
Morphine 11 98.60 Very High Very High Very High
narcan 6 98.12 Very High Very High Very High
Glutamate receptor 1 97.20 Very High Very High Very High
antagonist 2 89.72 High High
agonist 1 87.96 High High
anesthesia 1 63.16 Quite High
ketamine 1 62.36 Quite High
epidural 1 60.72 Quite High
Disease Link Frequency Relevance Heat
Convulsion 9 99.98 Very High Very High Very High
Absence Epilepsy 1 67.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these results indicate a spectrum of anticonvulsant action for the KD in rats that includes threshold seizures induced via GABA receptors (BIC, PIC, GBL) but not those induced at glycine (strychnine) or the KA-subclass of glutamate receptors.
Positive_regulation (induced) of GBL associated with convulsion, glutamate receptor, gaba receptor and anticonvulsant
1) Confidence 0.47 Published 2002 Journal Epilepsy Res. Section Abstract Doc Link 12200222 Disease Relevance 0.73 Pain Relevance 0.31
In rats treated with gamma-butyrolactone (GBL) or with reserpine DOPA accumulation was not altered by treatment with morphine or naloxone.
Positive_regulation (accumulation) of GBL associated with narcan and morphine
2) Confidence 0.30 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.25

General Comments

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