INT24983

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 17.56
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
body 2
macrophages 1
monocytes 1
chest 1
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 184 100.00 Very High Very High Very High
Paracetamol 22 100.00 Very High Very High Very High
Angina 26 99.66 Very High Very High Very High
Bioavailability 13 98.20 Very High Very High Very High
spastic colon 25 97.32 Very High Very High Very High
Inflammatory response 57 92.96 High High
rheumatoid arthritis 98 90.16 High High
imagery 14 90.16 High High
Infliximab 81 87.28 High High
headache 3 85.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 311 100.00 Very High Very High Very High
INFLAMMATION 248 100.00 Very High Very High Very High
Obesity 40 100.00 Very High Very High Very High
Insulin Resistance 36 100.00 Very High Very High Very High
Meningitis 13 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 43 99.96 Very High Very High Very High
Heart Disease 7 99.80 Very High Very High Very High
Angina 22 99.66 Very High Very High Very High
Infarction 18 99.24 Very High Very High Very High
Foreign Bodies 18 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After washing, specific antibody binding was detected using specific peroxidase conjugated secondary antibodies (Jackson Immunoresearch, West Grove, PA) or a biotinylated swine anti rabbit secondary antibody (E0432, DakoCytomation) for detecting MPO specific binding.
MPO Binding (binding) of associated with urological neuroanatomy
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.43 Pain Relevance 0.03
However, we found the strongest effect modification for MPO, an enzyme that binds to the vessel wall and depletes vascular NO bioavailability (Rudolph et al. 2006).
MPO Neg (NO) Binding (binds) of associated with urological neuroanatomy and bioavailability
2) Confidence 0.40 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.99 Pain Relevance 0.09
MPO is an enzyme that binds to the vessel wall, critically modulates structural and humoral integrity of the vessel wall, and depletes vascular NO bioavailability (Eiserich et al. 2002; Nicholls and Hazen 2005; Rudolph et al. 2006).
MPO Neg (NO) Binding (binds) of associated with urological neuroanatomy and bioavailability
3) Confidence 0.40 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.70 Pain Relevance 0.05
Clinical studies have suggested an association between levels of MPO and the presence of coronary artery disease and endothelial dysfunction, and have shown a possible additional role to troponin in patients with chest pain.
MPO Binding (association) of in chest associated with angina, coronary artery disease and urological neuroanatomy
4) Confidence 0.37 Published 2005 Journal Curr Atheroscler Rep Section Abstract Doc Link 15727728 Disease Relevance 0.99 Pain Relevance 0.09
Myeloperoxidase appears to be much more important in the binding of acetaminophen to DNA than it is in the DNA binding of arylamines in general.
Myeloperoxidase Binding (binding) of associated with paracetamol
5) Confidence 0.37 Published 1989 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2485128 Disease Relevance 0 Pain Relevance 0.69
infarction (AMI) and unstable angina (UA) have a low MPO content, and therefore
MPO Binding (content) of associated with angina, urological neuroanatomy and infarction
6) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.82 Pain Relevance 0.36
MPO is not likely to be specific for cardiac diseases, as activation of
MPO Spec (likely) Binding (specific) of associated with heart disease and urological neuroanatomy
7) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.77 Pain Relevance 0.16
Of interest in this study, serum MPO levels were associated
MPO Binding (associated) of associated with urological neuroanatomy
8) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.56 Pain Relevance 0.06
We present a case of HP associated with MPO-ANCA-positive vasculitis and emphasize the importance of MPO-ANCA tests as a predictable factor for relapse of the disease in order to start earlier treatment for the disease.
MPO-ANCA-positive Binding (associated) of associated with meningitis, urological neuroanatomy, disease, increased venous pressure under development and recurrence
9) Confidence 0.37 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 19727912 Disease Relevance 1.62 Pain Relevance 0.13
Interaction of acetaminophen with myeloperoxidase intermediates: optimum stimulation of enzyme activity.
myeloperoxidase Binding (Interaction) of associated with paracetamol
10) Confidence 0.37 Published 1993 Journal Arch. Biochem. Biophys. Section Title Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.49
Two cases of hypertrophic pachymeningitis associated with myeloperoxidase antineutrophil cytoplasmic autoantibody (MPO-ANCA)-positive pulmonary silicosis in tunnel workers.
myeloperoxidase Binding (associated) of associated with meningitis, urological neuroanatomy and occupational lung diseases
11) Confidence 0.36 Published 2004 Journal Clin. Rheumatol. Section Title Doc Link 14749992 Disease Relevance 1.40 Pain Relevance 0.16
Moreover, we analyzed effect modification by clinical characteristics associated with insulin resistance such as body mass index (BMI), glycosylated hemoglobin A1c (HbA1c), and adiponectin and by daily myeloperoxidase (MPO) level.
MPO Spec (analyzed) Binding (associated) of in body associated with obesity, urological neuroanatomy and insulin resistance
12) Confidence 0.31 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.72 Pain Relevance 0.04
Moreover, we analyzed effect modification by clinical characteristics associated with insulin resistance such as body mass index (BMI), glycosylated hemoglobin A1c (HbA1c), and adiponectin and by daily myeloperoxidase (MPO) level.
myeloperoxidase Spec (analyzed) Binding (associated) of in body associated with obesity, urological neuroanatomy and insulin resistance
13) Confidence 0.31 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.72 Pain Relevance 0.04
process appears to involve MPO because apocynin does not inhibit the oxidase in
MPO Binding (involve) of associated with urological neuroanatomy
14) Confidence 0.23 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.43 Pain Relevance 0
The authors also found that PMN-elastase and calprotectin levels were correlated with the endoscopically classified severity of inflammation but not the myeloperoxidase.34
myeloperoxidase Neg (not) Binding (were) of associated with inflammation
15) Confidence 0.19 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 0.86 Pain Relevance 0.27
C-ANCAs bind to the antigen proteinase 3 and result in a diffuse cytoplasmic staining pattern on immunofluorescence and are highly associated with Wegener's granulomatosis, while p-ANCAs bind to myeloperoxidase, have a perinuclear staining pattern, and are associated with microscopic polyangiitis and Churg-Strauss syndrome.
myeloperoxidase Binding (bind) of associated with syndrome and microscopic polyangiitis
16) Confidence 0.18 Published 2002 Journal BMC Neurol Section Body Doc Link PMC134471 Disease Relevance 0.84 Pain Relevance 0
For example, obtaining the list of ligands whose binding to the Oligomer is increased when compared to binding of the same ligand to the protomer is possible with our ontology, but not with the relations offered by MPO.
MPO Binding (binding) of associated with urological neuroanatomy
17) Confidence 0.11 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.56 Pain Relevance 0
Implant-associated myeloperoxidase (MPO) and non-specific esterase (NSE) were quantified to assess the numbers of adherent polymorphonuclear neutrophils [PMN] and macrophages/monocytes [MØ], respectively.
myeloperoxidase Binding (associated) of in monocytes associated with urological neuroanatomy
18) Confidence 0.11 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.85 Pain Relevance 0.21
Myeloperoxidase assay
Myeloperoxidase Binding (assay) of
19) Confidence 0.08 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.07 Pain Relevance 0
Positive sera were further tested for reactivity against myeloperoxidase and proteinase 3 by using an ELISA with an anti-human IgG (H+L) conjugate (Bioadvance, Emerainville, France).
myeloperoxidase Binding (reactivity) of
20) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.21 Pain Relevance 0.21

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