INT249843

Context Info Confidence 0.59 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.26 Pain Relevance 0.50

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)

Anatomy Link Frequency muscles 2 limb muscles 2 Fgf2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 4 94.44 cytokine 16 87.16 Inflammation 20 85.28 hypoalgesia 10 84.80 diabetic neuropathy 52 78.48 GABAergic 2 50.60 gABA 2 46.92 Kinase C 2 45.64 Nerve growth factor 28 5.00 neurotrophin 3 28 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 266 99.96 Ganglion Cysts 4 92.64 Apoptosis 10 85.84 INFLAMMATION 20 85.28 Hypoalagesia 10 84.80 Adhesions 2 82.32 Disease 6 81.20 Diabetic Neuropathy 54 78.48 Obesity 2 45.76 Stress 6 26.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS—VEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats.

Positive_regulation (increased) of Transcription (expression) of bFGF in muscles associated with diabetes mellitus

1) Confidence 0.59 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.64 Pain Relevance 0.24

In our study, bFGF and VEGF mRNA expressions in STZ-induced diabetic rats were upregulated in MSC-injected hind limb muscles, and MSCs maintained their viabilities and abilities to secrete bFGF and VEGF even 4 weeks after the transplantation.

Positive_regulation (induced) of Transcription (expressions) of bFGF in limb muscles associated with diabetes mellitus

2) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.26 Pain Relevance 0.15

Previously a sustained induction of Fgf2 mRNA levels in spite of insulin treatment at a one month time point has been reported [55].

Positive_regulation (induction) of Transcription (levels) of Fgf2

3) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.70 Pain Relevance 0.04

Our data agree with a previous report of upregulated Fgf2 protein levels after 3 months of diabetes in the Sprague Dawley rat [54].

Positive_regulation (upregulated) of Transcription (levels) of Fgf2 associated with diabetes mellitus

4) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.66 Pain Relevance 0.07

General Comments

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