INT249843

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
muscles 2
limb muscles 2
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 94.44 High High
cytokine 16 87.16 High High
Inflammation 20 85.28 High High
hypoalgesia 10 84.80 Quite High
diabetic neuropathy 52 78.48 Quite High
GABAergic 2 50.60 Quite High
gABA 2 46.92 Quite Low
Kinase C 2 45.64 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
neurotrophin 3 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 266 99.96 Very High Very High Very High
Ganglion Cysts 4 92.64 High High
Apoptosis 10 85.84 High High
INFLAMMATION 20 85.28 High High
Hypoalagesia 10 84.80 Quite High
Adhesions 2 82.32 Quite High
Disease 6 81.20 Quite High
Diabetic Neuropathy 54 78.48 Quite High
Obesity 2 45.76 Quite Low
Stress 6 26.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS—VEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats.
Positive_regulation (increased) of Transcription (expression) of bFGF in muscles associated with diabetes mellitus
1) Confidence 0.59 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.64 Pain Relevance 0.24
In our study, bFGF and VEGF mRNA expressions in STZ-induced diabetic rats were upregulated in MSC-injected hind limb muscles, and MSCs maintained their viabilities and abilities to secrete bFGF and VEGF even 4 weeks after the transplantation.
Positive_regulation (induced) of Transcription (expressions) of bFGF in limb muscles associated with diabetes mellitus
2) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.26 Pain Relevance 0.15
Previously a sustained induction of Fgf2 mRNA levels in spite of insulin treatment at a one month time point has been reported [55].
Positive_regulation (induction) of Transcription (levels) of Fgf2
3) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.70 Pain Relevance 0.04
Our data agree with a previous report of upregulated Fgf2 protein levels after 3 months of diabetes in the Sprague Dawley rat [54].
Positive_regulation (upregulated) of Transcription (levels) of Fgf2 associated with diabetes mellitus
4) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.66 Pain Relevance 0.07

General Comments

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