INT249847

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.36
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc)
Anatomy Link Frequency
limbs 2
muscles 1
bone marrow 1
limb muscles 1
Msc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 10 99.24 Very High Very High Very High
Spinal cord 50 95.36 Very High Very High Very High
Sciatic nerve 10 92.84 High High
Inflammation 5 89.60 High High
hypoalgesia 20 85.36 High High
cytokine 30 84.56 Quite High
diabetic neuropathy 104 81.52 Quite High
ischemia 3 53.48 Quite High
Neuropathic pain 10 41.28 Quite Low
allodynia 4 26.60 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 284 99.78 Very High Very High Very High
Spinal Cord Injury 114 95.36 Very High Very High Very High
Increased Venous Pressure Under Development 8 93.20 High High
INFLAMMATION 9 89.60 High High
Hypoalagesia 20 85.36 High High
Diabetic Neuropathy 108 81.52 Quite High
Disease 8 78.60 Quite High
Neurodegenerative Disease 6 77.56 Quite High
Atherosclerotic Plaque 1 77.04 Quite High
Coronary Artery Disease 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, eNOS production could be induced in the MSC-transplanted limbs of STZ-induced diabetic rats.
Positive_regulation (induced) of MSC-transplanted in limbs associated with diabetes mellitus
1) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.62 Pain Relevance 0.07
In our study, bFGF and VEGF mRNA expressions in STZ-induced diabetic rats were upregulated in MSC-injected hind limb muscles, and MSCs maintained their viabilities and abilities to secrete bFGF and VEGF even 4 weeks after the transplantation.
Positive_regulation (upregulated) of MSC in limb muscles associated with diabetes mellitus
2) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.26 Pain Relevance 0.16
Both expressions were significantly elevated in the MSC-transplanted limbs of STZ-induced diabetic rats but not in those of normal rats.
Positive_regulation (elevated) of MSC-transplanted in limbs associated with diabetes mellitus
3) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.60 Pain Relevance 0.09
RESULTS—VEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats.
Positive_regulation (increased) of MSC in muscles associated with diabetes mellitus
4) Confidence 0.26 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.64 Pain Relevance 0.24
Umbilical cord and Wharton's jelly derived MSC offer unique therapeutic characteristics in comparison to bone marrow MSC.
Positive_regulation (derived) of MSC in bone marrow
5) Confidence 0.13 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.59 Pain Relevance 0.07
Here we describe a protocol based on a combination of intrathecal administration of CD34 and placental derived MSC.
Positive_regulation (derived) of MSC associated with intrathecal
6) Confidence 0.13 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.40 Pain Relevance 0.18
Orlic and his group have also demonstrated the upregulation of MSC homing and differentiation with the use of G-CSF [24].
Positive_regulation (upregulation) of MSC
7) Confidence 0.11 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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