INT249860

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 5.80
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr17) plasma membrane (Gpr17) signal transducer activity (Gpr17)
Anatomy Link Frequency
neurons 3
brain 2
cortex 1
Gpr17 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 160 98.76 Very High Very High Very High
Multiple sclerosis 30 94.96 High High
imagery 70 92.64 High High
Spinal cord 10 90.16 High High
Central nervous system 20 88.32 High High
agonist 130 87.08 High High
antagonist 80 63.64 Quite High
cerebral cortex 20 15.28 Low Low
Inflammation 40 5.00 Very Low Very Low Very Low
Hippocampus 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 290 99.76 Very High Very High Very High
Cv Unclassified Under Development 110 98.76 Very High Very High Very High
Stress 20 98.56 Very High Very High Very High
Demyelinating Disease 60 98.00 Very High Very High Very High
Injury 70 97.84 Very High Very High Very High
Shock 10 97.80 Very High Very High Very High
Death 120 97.52 Very High Very High Very High
Cv General 4 Under Development 10 97.00 Very High Very High Very High
Brain Hemorrhage 80 95.72 Very High Very High Very High
Brain Injury 90 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initial up-regulation of GPR17 in neurons is followed by a second wave of receptor induction in microglial/macrophages recruited from distal parenchymal areas and moving towards the lesioned zone.
Regulation (regulation) of GPR17 in neurons
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.65 Pain Relevance 0.14
In the lesioned area, we observed an early and transient up-regulation of GPR17 in neurons expressing the cellular stress marker heat shock protein 70.
Regulation (regulation) of GPR17 in neurons associated with stress and shock
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2570486 Disease Relevance 0.84 Pain Relevance 0.16
Within the lesioned area, a strong up-regulation of GPR17 was observed 24 h after MCAo (Figure 5A) with respect to the corresponding unlesioned area of the contralateral cortex (Figure 5C).
Regulation (regulation) of GPR17 in cortex associated with middle cerebral artery infarction
3) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.42 Pain Relevance 0.11
To characterize the changes of GPR17 occurring during ischemic damage, mouse brains were processed for immunohistochemistry at 24, 48, 72 hours and 1 week after MCAo.
Regulation (changes) of GPR17 in brains associated with middle cerebral artery infarction
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.34 Pain Relevance 0.12
A quantification of the MCAo-induced up-regulation of GPR17 is shown in histograms.
Regulation (regulation) of GPR17 associated with middle cerebral artery infarction
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.45 Pain Relevance 0
Globally, these findings suggest that, upon damage, GPR17 is up-regulated in injured neurons and that this up-regulation may be causally related to cell death.
Regulation (regulated) of GPR17 in neurons associated with death
6) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.40 Pain Relevance 0
We have previously suggested that an up-regulation of the hybrid nucleotide/cysteinyl-leukotriene receptor GPR17 in the ischemic brain may contribute to the evolution of damage [11].
Regulation (regulation) of GPR17 in brain
7) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.45 Pain Relevance 0.06
This indicates GPR17 as a possible target for pharmacological intervention in neurodegeneration processes including cerebral ischemia and demyelinating diseases.


Spec (possible) Regulation (target) of GPR17 associated with cv general 4 under development, ischemia and demyelinating disease
8) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.97 Pain Relevance 0.17
This strongly indicates that GPR17 is indeed the specific target of 616, thus confirming a specific role for this receptor in the changes associated to ischemic damage development.


Regulation (target) of GPR17
9) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.46 Pain Relevance 0.07
Specifically, we suggest GPR17 as a novel target for therapeutic manipulation to foster repair of demyelinating wounds, the types of lesions that also occur in patients with multiple sclerosis.



Regulation (target) of GPR17 associated with multiple sclerosis, injury and demyelinating disease
10) Confidence 0.21 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2570486 Disease Relevance 0.82 Pain Relevance 0.11

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