INT249865

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr17) plasma membrane (Gpr17) signal transducer activity (Gpr17)
Anatomy Link Frequency
oligodendrocyte 2
Gpr17 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 39 100.00 Very High Very High Very High
Hippocampus 9 90.76 High High
antagonist 24 79.68 Quite High
ischemia 48 78.96 Quite High
imagery 21 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 33 78.96 Quite High
Middle Cerebral Artery Infarction 87 64.56 Quite High
Death 36 58.60 Quite High
Brain Injury 27 53.68 Quite High
Brain Hemorrhage 24 50.24 Quite High
Injury 21 5.00 Very Low Very Low Very Low
Demyelinating Disease 18 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several of these cells were also immunoreactive for GPR17 (red fluorescence in Figure 3A; cells expressing both S100?
Positive_regulation (immunoreactive) of Positive_regulation (fluorescence) of GPR17
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.06 Pain Relevance 0.08
The total number of cells in culture did not significantly increase during the 72 h treatment period with pharmacological agents, as suggested by labeling of cell nuclei with Hoechst 33258 (Figure 4L and 4M), to support the conclusion that, in these cultures, activation of GPR17 by its endogenous agonists is actually inducing the in vitro maturation of already existing oligodendrocyte precursors.
Positive_regulation (inducing) of Positive_regulation (activation) of GPR17 in oligodendrocyte associated with agonist
2) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.26 Pain Relevance 0.13
In treated cultures, the total number of cells was not increased, to suggest that activation of GPR17 is actually inducing the maturation of already existing precursors.
Positive_regulation (inducing) of Positive_regulation (activation) of GPR17
3) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.10 Pain Relevance 0.38

General Comments

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