INT249866

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.32
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr17) plasma membrane (Gpr17) signal transducer activity (Gpr17)
Anatomy Link Frequency
precursor cells 1
brain 1
Gpr17 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 40 99.50 Very High Very High Very High
agonist 65 94.48 High High
imagery 35 87.12 High High
Potency 5 79.92 Quite High
ischemia 80 60.00 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Multiple sclerosis 15 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 5 99.76 Very High Very High Very High
Death 60 95.88 Very High Very High Very High
Middle Cerebral Artery Infarction 145 84.08 Quite High
Brain Hemorrhage 40 74.36 Quite High
Targeted Disruption 15 71.76 Quite High
Cv Unclassified Under Development 55 60.00 Quite High
Injury 35 59.76 Quite High
Anaplastic Astrocytoma 10 59.56 Quite High
Brain Injury 45 40.20 Quite Low
Contagious Ecthyma 5 36.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A causal link between up-regulation of GPR17 and extent of brain damage was suggested by data showing that inhibition of GPR17 by either pharmacological agents or by an antisense-oligonucleotide strategy markedly attenuated cell death (ibidem).
Negative_regulation (inhibition) of GPR17 in brain associated with death
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.48 Pain Relevance 0
Finally, another group of 6 animals received Cangrelor, that, although not selective for GPR17 (see “Cloning and characterization of mouse GPR17”), has been shown by us to potently inhibit GPR17 in both the rat [11] and in the mouse (the present study).
Negative_regulation (inhibit) of GPR17
2) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.68 Pain Relevance 0.12
Interestingly, in c. striatum, immature GPR17+/MBP-negative precursor cells were often found physically associated to or inside myelin tracts, which have been previously shown to also contain immature Olig2+ cells [29].
Negative_regulation (immature) of GPR17 in precursor cells
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0
To further confirm the specificity of these results, in the mGPR17-expressing cells, pre-adsorption of the anti-receptor antibody with the neutralizing peptide utilized for immunization completely abolished the GPR17 signal (Figure S1C).
Negative_regulation (abolished) of GPR17 associated with immunization
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.16 Pain Relevance 0.03
Cangrelor, a P2Y12/13 antagonist, which displayed a high affinity towards human and rat GPR17 [11] concentration-dependently inhibited GTP?
Negative_regulation (affinity) of GPR17 associated with antagonist
5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.30

General Comments

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