INT249870

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.18
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr17) plasma membrane (Gpr17) signal transducer activity (Gpr17)
Anatomy Link Frequency
brain 3
precursor cells 1
Mouse 1
neurons 1
neural 1
Gpr17 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 99.44 Very High Very High Very High
ischemia 128 93.32 High High
cerebral cortex 16 84.56 Quite High
antagonist 64 65.44 Quite High
agonist 104 52.60 Quite High
Potency 8 38.04 Quite Low
imagery 56 19.56 Low Low
excitatory amino acid 8 16.16 Low Low
Inflammation 32 5.00 Very Low Very Low Very Low
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contagious Ecthyma 8 97.36 Very High Very High Very High
Middle Cerebral Artery Infarction 232 94.08 High High
Brain Hemorrhage 64 93.76 High High
Death 96 93.64 High High
Injury 56 91.84 High High
Brain Injury 72 91.12 High High
Cv Unclassified Under Development 88 90.76 High High
Demyelinating Disease 48 86.84 High High
Cv General 4 Under Development 8 85.76 High High
Anaplastic Astrocytoma 16 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Highly branched GPR17+ cells were also found in the subgranular layer of the hippocampus (Figure 3E); also here, no colocalization of GPR17 with the adult neural stem cell marker GFAP was found.
Localization (colocalization) of GPR17 in neural associated with hippocampus
1) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.08
On this basis, the present study has been specifically aimed at assessing the localization of GPR17 in cells of different lineages (neurons, glia and neural progenitor cells) of the intact mouse brain and its changes at different times after induction of focal cerebral ischemia in the MCAo model.
Localization (localization) of GPR17 in neurons associated with brain hemorrhage, middle cerebral artery infarction and ischemia
2) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.61 Pain Relevance 0.11
These parenchymal branched GPR17+ precursors were consistently found in the c. striatum (indicated as 2 in brain drawing) as well as in regions closer to the lesion borders.
Localization (found) of GPR17 in brain
3) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.18 Pain Relevance 0
Furthermore, no colocalization of GPR17 was found with more mature myelinating oligodendroglial markers, as shown by lack of double-staining with either CNPase (Figure 2I), myelin-associated glycoprotein MAG (Figure 2J) and myelin basic protein MBP or APC (data not shown), suggesting that GPR17 may be expressed at a specific stage of oligodendroglial differentiation.
Localization (colocalization) of GPR17
4) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.06 Pain Relevance 0.03
Interestingly, in c. striatum, GPR17+ precursor cells were not positive for MBP, but were often found physically associated to or inside myelinating fibers (Figure S2).
Localization (precursor cells) of GPR17 in precursor cells
5) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.09 Pain Relevance 0.08
We then utilized the specific anti-GPR17 antibody to determine the cellular localization of GPR17 in control mouse brain.
Spec (determine) Localization (localization) of GPR17 in brain
6) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.16
On this basis, the present study was purposely undertaken to (i) define the cellular localization of GPR17 in the intact mouse brain and shed light on its potential roles under physiological conditions; and (ii), to define possible changes of this receptor in the cell types that participate to brain damage and repair in a well-established focal ischemia model such as the MCAo model in the mouse.


Localization (localization) of GPR17 in brain associated with middle cerebral artery infarction and ischemia
7) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.41 Pain Relevance 0.05
Mouse GPR17, which is localized on chromosome 18, contains a 1020 base pairs open reading frame (ORF) that encodes for a putative 339 amino acid protein 90 and 98% identical to human and rat GPR17 [11].
Localization (localized) of GPR17 in Mouse associated with contagious ecthyma
8) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.83 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox