INT24989

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 125
Total Number 126
Disease Relevance 29.55
Pain Relevance 64.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
PFC 25
neurons 9
amygdala 6
brain 5
hippocampus 4
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1853 100.00 Very High Very High Very High
Nucleus accumbens 1712 100.00 Very High Very High Very High
Hippocampus 865 100.00 Very High Very High Very High
noradrenaline 794 100.00 Very High Very High Very High
Locus ceruleus 405 100.00 Very High Very High Very High
depression 165 100.00 Very High Very High Very High
Ventral tegmentum 141 100.00 Very High Very High Very High
long-term potentiation 111 100.00 Very High Very High Very High
fluoxetine 88 100.00 Very High Very High Very High
Glutamate 70 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 212 100.00 Very High Very High Very High
Nociception 154 100.00 Very High Very High Very High
Persistent Fetal Circulation Syndrome 10 100.00 Very High Very High Very High
Cognitive Disorder 213 99.96 Very High Very High Very High
Hypersensitivity 16 99.92 Very High Very High Very High
Stress 783 99.90 Very High Very High Very High
Anxiety Disorder 778 99.88 Very High Very High Very High
Sleep Disorders 429 99.84 Very High Very High Very High
Pain 250 99.80 Very High Very High Very High
Li-fraumeni Syndrome 84 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such behaviors also activate the PFC, and simultaneous recordings in the hippocampus and PFC revealed a strong coupling between both structures in the theta range, as well as correlated cell firing during spatial working memory tasks [16].
Positive_regulation (activate) of PFC in hippocampus associated with hippocampus
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.59
As the PFC-NA and VH-NA connections are not reciprocal (both areas send heavy monosynaptic projections to the NA), the coherence data suggest that NA core follows VH activity during spatial exploration, but follows PFC activity during an operant task, even in the presence of similar spatial information.
Positive_regulation (follows) of PFC associated with nucleus accumbens and hippocampus
2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.89
Unlike single-pulse stimulation [12], electrical stimulation of PFC with trains of pulses (5 pulses at 50 Hz) evoked sustained depolarizations similar to up states in NA core MSNs of anesthetized rats (n?
Positive_regulation (stimulation) of PFC associated with nucleus accumbens
3) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.66
Furthermore, delta oscillations in humans increase significantly while performing the Wisconsin Card Sorting Test [36], which typically activates the PFC.
Positive_regulation (activates) of PFC
4) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.19
As a consequence, epochs with increased PFC firing such as during reward-seeking behavior could drive NA core cell firing by virtue of the tight control of NA MSN membrane potential by PFC bursts.
Positive_regulation (increased) of PFC associated with nucleus accumbens
5) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.40
We found that D2 agonist-elicited increases in PFC GABA levels were blocked by pretreatment with SR48692, consistent with data indicating that D2 autoreceptor agonists increase neurotensin release from dopamine-neurotensin axons in the PFC.
Positive_regulation (increases) of PFC in PFC associated with dopamine, gaba and agonist
6) Confidence 0.53 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15716398 Disease Relevance 0.06 Pain Relevance 0.75
These results suggest that the behavioral abnormalities induced by acute administration of phencyclidine may be caused by hyperactivation of mPFC neurons, and that this hyperactivation is elicited through excitatory inputs from brain regions outside the mPFC.
Positive_regulation (hyperactivation) of mPFC in brain associated with congenital anomalies
7) Confidence 0.46 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220577 Disease Relevance 0.10 Pain Relevance 0.15
In addition, chronic, but not acute, fluoxetine treatment significantly suppressed the firing and excitability of PFC neurons.
Positive_regulation (excitability) of PFC in neurons associated with fluoxetine
8) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951202 Disease Relevance 0 Pain Relevance 0.84
In conclusion, chronic, but not acute, olanzapine treatment significantly enhanced the firing and excitability of PFC neurons.
Positive_regulation (enhanced) of PFC in PFC
9) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951202 Disease Relevance 0.11 Pain Relevance 0.86
These findings suggest that PCP-induced activation of mPFC neurons is elicited mainly via excitatory inputs from regions outside the mPFC.
Positive_regulation (activation) of mPFC in neurons
10) Confidence 0.43 Published 2005 Journal Cereb. Cortex Section Abstract Doc Link 15342431 Disease Relevance 0.17 Pain Relevance 0.22
We investigated the absolute concentration of N-acetylaspartate (NAA) in the anterior cingulated cortex (ACC), and prefrontal cortex (PFC) in chronic pain patients by proton magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects.
Positive_regulation (cingulated) of PFC in thalamus associated with lasting pain, thalamus and anterior cingulate
11) Confidence 0.42 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411706 Disease Relevance 0.27 Pain Relevance 0.56
Further, short-term olanzapine treatment attenuated the suppression of firing and excitability of PFC neurons induced by chronic fluoxetine treatment.
Positive_regulation (induced) of PFC in PFC associated with fluoxetine
12) Confidence 0.41 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951202 Disease Relevance 0 Pain Relevance 0.81
A multi-taper spectral analysis [15] allowed us to calculate spectral density over short time intervals, revealing that the increase in delta power in the NA core and PFC occurred during the 1–2 second interval between the cue and lever press (arrows in Figure 2B).
Positive_regulation (increase) of PFC in lever associated with nucleus accumbens
13) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.45
Our in vivo data from anesthetized rats reveal that strong PFC activation with a bursty pattern similar to what has been reported in behaving rodents [20], [21] can drive persistent depolarizations in the NA [39].
Positive_regulation (activation) of PFC associated with nucleus accumbens
14) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.36
The term switchboard is used here to represent a feature in the integration of inputs and intrinsic activity that may allow strong PFC activity to overcome the normally tight following of hippocampal inputs typically observed in the NA.
Positive_regulation (allow) of PFC associated with nucleus accumbens
15) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.42
During reward-seeking behavior, strong PFC activation may be able to override the tight NA correlation with VH theta rhythms that characterized the exploratory period.
Positive_regulation (activation) of PFC associated with nucleus accumbens and hippocampus
16) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.75
This switch may be interpreted as a brief activation of the PFC being able to drive active states in the NA and override the hippocampal influence.
Positive_regulation (activation) of PFC associated with nucleus accumbens
17) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.40
The core-shell difference in delta events during the task may allow some speculation that shell and core regions respond differently to medial PFC activation, and may have different roles in response selection.
Positive_regulation (activation) of PFC in shell
18) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.28
In vivo intracellular recordings tested this possibility and indeed showed that brief PFC activation can sometimes drive NA up states.
Positive_regulation (activation) of PFC associated with nucleus accumbens
19) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.35
We tested this possibility by stimulating the PFC with a bursty pattern similar to what observed in awake rats during goal-directed behavior [20].
Positive_regulation (stimulating) of PFC
20) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.65

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