INT2499

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2009
Negated 5
Speculated 3
Reported most in Abstract
Documents 51
Total Number 54
Disease Relevance 2.83
Pain Relevance 32.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 18
brain 2
striatum 2
ganglion 2
plasma 1
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 228 100.00 Very High Very High Very High
Morphine 146 99.84 Very High Very High Very High
Nucleus accumbens 3 99.84 Very High Very High Very High
noradrenaline 14 99.76 Very High Very High Very High
antagonist 56 99.54 Very High Very High Very High
narcan 66 99.48 Very High Very High Very High
tetrodotoxin 26 99.40 Very High Very High Very High
Enkephalin 45 99.26 Very High Very High Very High
adenocard 15 99.18 Very High Very High Very High
Hippocampus 4 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 98.96 Very High Very High Very High
Urological Neuroanatomy 4 90.08 High High
Stress 5 89.48 High High
Galactorrhea 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The (+)-isomer induced no DOPA release.
Neg (no) Positive_regulation (induced) of DOPA
1) Confidence 0.43 Published 1990 Journal Brain Res. Section Abstract Doc Link 2119849 Disease Relevance 0 Pain Relevance 0.65
No effect of morphine was observed on DOPA accumulation in the median eminence of NSD-treated rats that had received 50 ng of morphine sulfate intracerebroventricularly, and only a 50% reduction was observed in the accumulation of DOPA in the median eminence of rats given 500 ng of morphine sulfate.
Positive_regulation (accumulation) of DOPA in median eminence associated with morphine
2) Confidence 0.40 Published 1983 Journal Brain Res. Section Abstract Doc Link 6404502 Disease Relevance 0 Pain Relevance 1.17
No effect of morphine was observed on DOPA accumulation in the median eminence of NSD-treated rats that had received 50 ng of morphine sulfate intracerebroventricularly, and only a 50% reduction was observed in the accumulation of DOPA in the median eminence of rats given 500 ng of morphine sulfate.
Positive_regulation (accumulation) of DOPA in median eminence associated with morphine
3) Confidence 0.40 Published 1983 Journal Brain Res. Section Abstract Doc Link 6404502 Disease Relevance 0 Pain Relevance 1.12
Tyrosine methylester increased DOPA concentrations in all brain areas studied.
Positive_regulation (increased) of DOPA in brain
4) Confidence 0.32 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6123552 Disease Relevance 0.09 Pain Relevance 0.35
Since the effects of morphine on the apomorphine-induced inhibition of DOPA accumulation were antagonized by naloxone, we suggest that the effects on striatal DOPA accumulation produced by morphine were mediated via opioid receptors and not directly via DA receptors.
Positive_regulation (accumulation) of DOPA associated with narcan, opioid receptor and morphine
5) Confidence 0.29 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.22
Furthermore, the stimulation of DOPA accumulation in the median eminence induced by db-cAMP was additive with that induced by high potassium depolarization, which was Ca2+ -dependent.
Positive_regulation (accumulation) of DOPA in median eminence
6) Confidence 0.23 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.33
Addition of dibutyryl cAMP (db-cAMP) into medium caused an increase in the rate of DOPA accumulation in the median eminence in a dose- and time-dependent manner. 8-Bromo-cAMP also increased the rate of DOPA accumulation in the median eminence and cAMP was less effective than db-cAMP whereas neither adenosine nor sodium butyrate altered the rate of DOPA accumulation.
Positive_regulation (accumulation) of DOPA in median eminence associated with adenocard
7) Confidence 0.23 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.33
Peripheral administration of L-3,4-dihydroxyphenylalanine (L-DOPA) methylester increased extracellular levels of DOPA and dopamine (DA) in the rat striatum monitored by in vivo brain microdialysis.
Positive_regulation (increased) of DOPA in brain associated with dopamine
8) Confidence 0.22 Published 1992 Journal Life Sci. Section Abstract Doc Link 1325018 Disease Relevance 0 Pain Relevance 0.38
In rats treated with gamma-butyrolactone (GBL) or with reserpine DOPA accumulation was not altered by treatment with morphine or naloxone.
Positive_regulation (accumulation) of DOPA associated with narcan and morphine
9) Confidence 0.21 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.24
In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio).
Positive_regulation (accumulated) of DOPA associated with dopamine
10) Confidence 0.20 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.45
Naloxone did not significantly change the accumulation of DOPA after apomorphine or after haloperidol.
Positive_regulation (accumulation) of DOPA associated with narcan
11) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.14
The DA agonist apomorphine decreased and the DA antagonist haloperidol increased DOPA accumulation.
Positive_regulation (accumulation) of DOPA associated with antagonist and agonist
12) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.10
Acute systemic administration of morphine (10 mg/kg s.c.) to rats increased in vivo tyrosine hydroxylation in the striatum measured as the accumulation of DOPA after decarboxylase inhibition.
Positive_regulation (accumulation) of DOPA in striatum associated with morphine
13) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 0.75
Since the effects of morphine on the apomorphine-induced inhibition of DOPA accumulation were antagonized by naloxone, we suggest that the effects on striatal DOPA accumulation produced by morphine were mediated via opioid receptors and not directly via DA receptors.
Positive_regulation (accumulation) of DOPA associated with narcan, opioid receptor and morphine
14) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.18
Effect of morphine on the accumulation of DOPA after decarboxylase inhibition in the rat.
Positive_regulation (accumulation) of DOPA associated with narcan and morphine
15) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 456411 Disease Relevance 0 Pain Relevance 1.09
The morphine antagonist naloxone (1, 10 or 100 mg/kg s.c.) did not significantly after DOPA accumulation.
Neg (not) Positive_regulation (accumulation) of DOPA associated with antagonist, narcan and morphine
16) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 0.96
However, the inhibiting effect of apomorphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (10 mg/kg s.c.).
Positive_regulation (accumulation) of DOPA associated with morphine
17) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.26
DOPA accumulation reached a maximum 30-60 min after morphine.
Positive_regulation (accumulation) of DOPA associated with morphine
18) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 0.85
However, the inhibiting effect of apomorphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (10 mg/kg s.c.).
Positive_regulation (accumulation) of DOPA associated with morphine
19) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.25
In striata ipsilateral to the lesion, the DOPA/DA ratio was elevated 4-fold, and the DOPA/DA and HVA/DA ratios were elevated 2-fold as compared to values in contralateral striata.
Positive_regulation (elevated) of DOPA associated with dopamine
20) Confidence 0.18 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858830 Disease Relevance 0 Pain Relevance 0.67

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