INT249912

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.49
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 86.48 High High
antagonist 24 81.00 Quite High
Serotonin 10 75.84 Quite High
sSRI 2 62.28 Quite High
fluoxetine 6 54.24 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 300 100.00 Very High Very High Very High
INFLAMMATION 16 86.48 High High
Hypoxia 74 83.48 Quite High
Hypertrophy 72 66.96 Quite High
Hyperplasia 2 21.76 Low Low
Disease 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Natriuresis 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, suppression of PAH activity with DMOG also increased the resting NO release, despite a weak effect comparing with that of the CPX.
Neg (NO) Positive_regulation (increased) of Negative_regulation (suppression) of PAH
1) Confidence 0.43 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.45 Pain Relevance 0
Oral sildenafil, a PDE5 inhibitor, prevented (in a study in which sildenafil was given 1 day after MCT) and reversed (in a study in which sildenafil was given 3 weeks after MCT) the development of PAH in MCT-treated rats, associated with a reduction in the ETA-receptor density in SMCs of pulmonary small arteries (diameter < 100??
Positive_regulation (after) of Negative_regulation (development) of PAH associated with pulmonary hypertension
2) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.03 Pain Relevance 0.34
Oral sildenafil, a PDE5 inhibitor, prevented (in a study in which sildenafil was given 1 day after MCT) and reversed (in a study in which sildenafil was given 3 weeks after MCT) the development of PAH in MCT-treated rats, associated with a reduction in the ETA-receptor density in SMCs of pulmonary small arteries (diameter < 100??
Positive_regulation (after) of Negative_regulation (development) of PAH associated with pulmonary hypertension
3) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.00 Pain Relevance 0.30

General Comments

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