INT249962

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.69
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT, KITLG) extracellular space (KIT, KITLG) plasma membrane (KIT, KITLG)
cytoplasm (KIT, KITLG) cell proliferation (KITLG) extracellular region (KITLG)
Anatomy Link Frequency
stem cell 3
bone marrow 2
islets of Langerhans 2
KIT (Homo sapiens)
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 92.04 High High
chemokine 2 78.24 Quite High
Inflammatory response 1 74.76 Quite High
cytokine 7 48.44 Quite Low
ischemia 1 24.60 Low Low
Inflammation 10 24.12 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 4 99.76 Very High Very High Very High
Apoptosis 2 97.72 Very High Very High Very High
Disease 134 86.24 High High
Conjunctiva Disease 32 85.16 High High
Recurrence 27 84.60 Quite High
Wound Healing 14 84.52 Quite High
Cancer 94 81.68 Quite High
Gastrointestinal Stromal Tumor 208 80.56 Quite High
Ulcers 29 80.08 Quite High
INFLAMMATION 10 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When c-kit receptors, which are produced by mesenchymal cells, bind to human stem cell factor (SCF) (also termed c-kit ligand) it will augment the proliferation of primitive bone marrow progenitor cells and differentiated mast cells.30-32 The fibroblast-like stem cells express the c-kit, suggestive of mesenchymal differentiation.21 STRO-1 is a monoclonal antibody that was shown to recognize all the clonogenic mesenchymal stem cells in human bone marrow fibroblast-like cells and to various nonhematopoietic progenitor cells.33,34 Hematopoietic and mesenchymal stem cells detected in Mooren's ulcer cornea in this study may be considered to be evidence of the involvement of bone marrow-derived progenitor cells in the pathogenesis of Mooren's ulcer.
c-kit Binding (bind) of SCF in bone marrow associated with ulcers
1) Confidence 0.19 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.40 Pain Relevance 0
The c-kit receptor binds to human stem cell factor and is involved in the development of several lineages of stem cells, such as germ cells and hematopoietic precursor cells, as well as in erythropoiesis and mast cell proliferation.13 AC133 is a stem cell antigen that may be useful for the selection of hematopoietic cells and vascular endothelium and may also be used as a positive marker for the characterization of the trophoblast cell line.14 The majority of cells reactive to AC133 antibodies have been found to co-express CD34 and c-kit.15 STRO-1 antigen is expressed by human bone marrow fibroblast-like cells and by various nonhematopoietic progenitor cells.16 On the basis of these reports, we performed immunohistochemical staining with a temporary amniotic membrane, applied to the bare sclera after pterygium excision, using various progenitor cell markers to investigate the involvement of bone marrow-derived progenitor cells in the wound healing process.


c-kit Binding (binds) of stem cell factor in bone marrow associated with conjunctiva disease and wound healing
2) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.51 Pain Relevance 0.04
SCF/c-kit interaction plays a very important role in the development, function, and survival of rodent islets of Langerhans [14, 15].
c-kit Binding (interaction) of SCF in islets of Langerhans
3) Confidence 0.02 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
SCF/c-kit interaction plays a very important role in the development, function, and survival of rodent islets of Langerhans [14, 15].
c-kit Binding (interaction) of SCF in islets of Langerhans
4) Confidence 0.02 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
The binding of the KIT-ligand (stem cell factor) to KIT-RTK results in homodimerization and autophosphorylation of the RTK with subsequent kinase activation.
KIT Binding (binding) of stem cell factor in stem cell
5) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.34 Pain Relevance 0.05
The binding of the KIT-ligand (stem cell factor) to KIT-RTK results in homodimerization and autophosphorylation of the RTK with subsequent kinase activation.
KIT-RTK Binding (binding) of stem cell factor in stem cell
6) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.34 Pain Relevance 0.05
Other than SDF-1, SCF is also involved in the regulation of stem cells migration by binding to its tyrosine kinase receptor, c-kit, which is expressed on a variety of stem cell lines [27].
c-kit Binding (binding) of SCF in stem cell
7) Confidence 0.00 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.10 Pain Relevance 0.04

General Comments

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