INT249978

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.94
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
carotid body 4
glomus 2
Igkv4-55 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 5 72.08 Quite High
Neurotransmitter 10 69.08 Quite High
Catecholamine 15 67.80 Quite High
imagery 5 20.72 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
halothane 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 270 100.00 Very High Very High Very High
Apoptosis 5 34.88 Quite Low
Acidosis 10 5.00 Very Low Very Low Very Low
Pituitary Cancer 5 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Dementia 5 5.00 Very Low Very Low Very Low
Cardiovascular Disease 5 5.00 Very Low Very Low Very Low
Diuresis 5 5.00 Very Low Very Low Very Low
Myocardial Infarction 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, hypoxia induces an upregulation of the expression of AT4 receptors in the glomus cells of the carotid body with an increase in the Ang IV-induced [Ca2+]i elevation.
Positive_regulation (upregulation) of Gene_expression (expression) of AT4 in glomus associated with hypoxia
1) Confidence 0.04 Published 2007 Journal The open cardiovascular medicine journal Section Abstract Doc Link PMC2570565 Disease Relevance 0.66 Pain Relevance 0
Additionally, the intensity of the staining was at a high level in the CH comparing with that of the Nx group, indicating an increase in AT4 receptor expression in the CH carotid body.
Positive_regulation (increase) of Gene_expression (expression) of AT4 in carotid body associated with hypoxia
2) Confidence 0.04 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.57 Pain Relevance 0.04
Our results suggest an upregulation of the expression of AT4 receptors in the carotid body in chronic hypoxia.
Positive_regulation (upregulation) of Gene_expression (expression) of AT4 in carotid body associated with hypoxia
3) Confidence 0.04 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.39 Pain Relevance 0.07
Quantitatively, the expression of AT4 receptors had a 2-fold increase in the CH carotid bodies comparing with the Nx control.
Positive_regulation (increase) of Gene_expression (expression) of AT4 associated with hypoxia
4) Confidence 0.03 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.51 Pain Relevance 0.06
Also, the protein level of AT4 receptor was doubled in the CH comparing with the Nx group, supporting an upregulation of the expression in hypoxia.
Positive_regulation (upregulation) of Gene_expression (expression) of AT4 associated with hypoxia
5) Confidence 0.03 Published 2007 Journal The open cardiovascular medicine journal Section Abstract Doc Link PMC2570565 Disease Relevance 0.81 Pain Relevance 0

General Comments

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