INT249996

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.25 Pain Relevance 0

extracellular space (ICAM1) extracellular region (GPHA2) cell adhesion (ICAM1) plasma membrane (ICAM1)

Anatomy Link Frequency endothelial cells 1 leukocytes 1 platelets 1 ICAM1 (Homo sapiens) GPHA2 (Homo sapiens)

Pain Link Frequency Relevance Heat noradrenaline 57 36.40 Potency 15 5.00 agonist 12 5.00 anesthesia 6 5.00 5HT 6 5.00 halothane 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Adhesions 3 99.80 Increased Venous Pressure Under Development 165 94.68 Hyperplasia 3 76.72 Hypertrophy 3 76.08 Cv Unclassified Under Development 21 50.24 Disease 21 5.00 Obesity 9 5.00 Congenital Anomalies 6 5.00 Diabetes Mellitus 3 5.00 Hypothermia 3 5.00

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nevertheless, it has been reported that a significant increase in endothelial adhesion molecule ICAM-1, associated with more thromboxane A2 and prostaglandin E2 synthesis, and with an increased interaction among leukocytes, platelets and endothelial cells, is observed in varicose veins [24, 25].

ICAM-1 Binding (associated) of A2 in leukocytes associated with increased venous pressure under development and adhesions

1) Confidence 0.02 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570569 Disease Relevance 0.75 Pain Relevance 0

Nevertheless, it has been reported that a significant increase in endothelial adhesion molecule ICAM-1, associated with more thromboxane A2 and prostaglandin E2 synthesis, and with an increased interaction among leukocytes, platelets and endothelial cells, is observed in varicose veins [24, 25].

ICAM-1 Binding (associated) of A2 in endothelial cells associated with increased venous pressure under development and adhesions

2) Confidence 0.01 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570569 Disease Relevance 0.75 Pain Relevance 0

Nevertheless, it has been reported that a significant increase in endothelial adhesion molecule ICAM-1, associated with more thromboxane A2 and prostaglandin E2 synthesis, and with an increased interaction among leukocytes, platelets and endothelial cells, is observed in varicose veins [24, 25].

ICAM-1 Binding (associated) of A2 in platelets associated with increased venous pressure under development and adhesions

3) Confidence 0.01 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570569 Disease Relevance 0.75 Pain Relevance 0

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