INT25

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Context Info
Confidence 0.67
First Reported 1976
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 8.64
Pain Relevance 7.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMC2) extracellular region (LAMC2) cell adhesion (LAMC2)
Anatomy Link Frequency
CSF 5
macrophage 1
dorsal 1
thyroid 1
brain 1
LAMC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
neuralgia 2 100.00 Very High Very High Very High
deep brain stimulation 1 100.00 Very High Very High Very High
Opioid 11 99.96 Very High Very High Very High
Serotonin 2 99.96 Very High Very High Very High
Dorsal column 3 99.84 Very High Very High Very High
intrathecal 15 99.68 Very High Very High Very High
Multiple sclerosis 11 99.24 Very High Very High Very High
Pain 13 98.96 Very High Very High Very High
depression 8 98.54 Very High Very High Very High
fluoxetine 4 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 11 99.92 Very High Very High Very High
Neurodegenerative Disease 1 99.92 Very High Very High Very High
Disease 31 99.46 Very High Very High Very High
Demyelinating Disease 11 99.24 Very High Very High Very High
Dementia 2 99.24 Very High Very High Very High
Lymphocytosis 24 99.16 Very High Very High Very High
Pain 10 98.96 Very High Very High Very High
Hypercapnia 2 98.60 Very High Very High Very High
Depression 9 98.54 Very High Very High Very High
Hypocapnia 2 97.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increases in levels of CSF serotonin and beta endorphin were recorded post stimulation.
Positive_regulation (increases) of CSF associated with serotonin
1) Confidence 0.67 Published 1996 Journal Integr Physiol Behav Sci Section Abstract Doc Link 8809593 Disease Relevance 0.32 Pain Relevance 0.49
Laboratory studies showed gradual increase of CSF proteins (from 156 mg/dl to 602 mg/dl) and extremely increased platelet aggregation.
Positive_regulation (increase) of CSF in platelet
2) Confidence 0.67 Published 1992 Journal Rinsho Shinkeigaku Section Abstract Doc Link 1628433 Disease Relevance 1.51 Pain Relevance 0.16
It has been demonstrated in a number of animal and human studies that sucrose ingestion increases the hypothalamic/CSF opioid levels.
Positive_regulation (increases) of CSF associated with opioid
3) Confidence 0.67 Published 2005 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 16579391 Disease Relevance 0.25 Pain Relevance 1.23
CONCLUSIONS: Sevoflurane, at 0.5 and 1.0 MAC, increases lumbar CSF pressure.
Positive_regulation (increases) of CSF in CSF
4) Confidence 0.67 Published 1999 Journal Anesthesiology Section Body Doc Link 10422937 Disease Relevance 0 Pain Relevance 0
We conclude that CSF analysis may not be necessary in the routine evaluation of patients presenting with a typical clinical profile of acute ON, and that most CSF tests add little additional information to MRI results for predicting the 2-year development of CDMS.
Neg (not) Spec (may) Positive_regulation (necessary) of CSF associated with multiple sclerosis and neuritis
5) Confidence 0.49 Published 1996 Journal Neurology Section Abstract Doc Link 8614496 Disease Relevance 1.45 Pain Relevance 0.90
Intrathecal administration induces much higher CSF concentrations compared to the limited passage through the blood-brain barrier after oral administration.
Positive_regulation (induces) of CSF in brain associated with intrathecal
6) Confidence 0.49 Published 2007 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17691379 Disease Relevance 0.43 Pain Relevance 0.29
In contrast, increasing concentrations of IL-3 or granulocyte-macrophage CSF overcome glyburide inhibition.
Positive_regulation (increasing) of CSF in macrophage
7) Confidence 0.49 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9605159 Disease Relevance 0.32 Pain Relevance 0.39
CSF NOC/oFQ concentration was elevated from 70+/-6 to 444+/-56 pg/ml ( approximately 10(-10) M) within 1 h of FPI.
Positive_regulation (elevated) of CSF associated with brain injury
8) Confidence 0.45 Published 2000 Journal Brain Res. Section Abstract Doc Link 10865080 Disease Relevance 0.60 Pain Relevance 0.83
In previous primate studies, in comparison to predictably reared controls, monkeys exposed as infants to maternal variable foraging demand (VFD) rearing exhibited persistent elevations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF), as well as other biological disturbances.
Positive_regulation (elevations) of CSF in CSF
9) Confidence 0.45 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10963795 Disease Relevance 0.09 Pain Relevance 0.49
Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS
Positive_regulation (Elevated) of CSF associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.45 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1187874 Disease Relevance 0.20 Pain Relevance 0.04
It was found that: 1) end-tidal CO2 may be used as a substitute for arterial PaCO2 determinations; 2) this elevation of CSFP has little effect on ICBF during hypercapnia and normocapnia; however, 3) during hypocapnia the ICBF is reduced an additional 20% when CSFP is elevated; that is, ICBF is reduced 50% from normal when end-tidal CO2 is reduced to 2% at this elevated level of CSFP.
Positive_regulation (elevation) of CSF associated with hypocapnia and hypercapnia
11) Confidence 0.45 Published 1976 Journal J. Neurosurg. Section Abstract Doc Link 2653 Disease Relevance 0.49 Pain Relevance 0.19
CSF 6-ketoPGF1 alpha and TXB2 levels increased by 152% and 80%, respectively (p < 0.001), but PGE2 decreased by 76% (p < 0.001), at 6 hours of infusion.
Positive_regulation (increased) of CSF
12) Confidence 0.45 Published 1996 Journal J. Investig. Med. Section Body Doc Link 8795299 Disease Relevance 0 Pain Relevance 0
It was found that: 1) end-tidal CO2 may be used as a substitute for arterial PaCO2 determinations; 2) this elevation of CSFP has little effect on ICBF during hypercapnia and normocapnia; however, 3) during hypocapnia the ICBF is reduced an additional 20% when CSFP is elevated; that is, ICBF is reduced 50% from normal when end-tidal CO2 is reduced to 2% at this elevated level of CSFP.
Positive_regulation (elevated) of CSF associated with hypocapnia and hypercapnia
13) Confidence 0.45 Published 1976 Journal J. Neurosurg. Section Abstract Doc Link 2653 Disease Relevance 0.55 Pain Relevance 0.21
Data from the one patient with Pick's disease demonstrates that reduced CSF levels of neurophysins and hormones is not confined to Alzheimer-type dementia.
Neg (not) Positive_regulation (confined) of CSF in CSF associated with dementia and disease
14) Confidence 0.45 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.45 Pain Relevance 0.11
The LCSF beta-EP concentration was not affected by deep brain stimulation, but was increased by dorsal column stimulation.
Neg (not) Positive_regulation (increased) of CSF in dorsal associated with deep brain stimulation and dorsal column
15) Confidence 0.45 Published 1985 Journal No To Shinkei Section Abstract Doc Link 2416330 Disease Relevance 0.54 Pain Relevance 0.80
Elevation of immunoreactive CSF TRH in depressed patients.
Positive_regulation (Elevation) of CSF associated with neuralgia
16) Confidence 0.45 Published 1988 Journal Am J Psychiatry Section Title Doc Link 3143269 Disease Relevance 0.28 Pain Relevance 0.18
The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in depression.
Positive_regulation (elevation) of CSF in thyroid associated with depression
17) Confidence 0.45 Published 1988 Journal Am J Psychiatry Section Abstract Doc Link 3143269 Disease Relevance 0.36 Pain Relevance 0.09
The lumbar CSF pressure was increased above 20 cm water in 79% and above 25 cm water in 42% in the obese patients.
Positive_regulation (increased) of CSF in CSF
18) Confidence 0.45 Published 1995 Journal Int. J. Obes. Relat. Metab. Disord. Section Body Doc Link 7627247 Disease Relevance 0.07 Pain Relevance 0
Fluoxetine also significantly decreased mean Hamilton Depression Rating Scale scores from 23.2 +/- 6.5 to 17.4 +/- 5.0 and significantly increased the CSF HVA/5-HIAA ratio.
Positive_regulation (increased) of CSF in CSF associated with depression and fluoxetine
19) Confidence 0.45 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 7687151 Disease Relevance 0.25 Pain Relevance 0.55
Of most interest, was the early appearance of CSF lymphocytosis compared to the later absence of CSF lymphocytosis (P = 0.0007), contrasting with the early absence of CSF-specific oligoclonal bands compared to their later presence (P = 0.0067) (data for individual cases shown in Supplementary Fig. 4).
Positive_regulation (absence) of CSF in bands associated with lymphocytosis
20) Confidence 0.17 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.49 Pain Relevance 0.09

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