INT250

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2010
Negated 7
Speculated 6
Reported most in Abstract
Documents 65
Total Number 78
Disease Relevance 17.46
Pain Relevance 23.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
plasma 14
follicle 3
thyroid 2
pituitary 2
gut 1
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 113 100.00 Very High Very High Very High
narcan 71 100.00 Very High Very High Very High
Somatostatin 35 100.00 Very High Very High Very High
agonist 24 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Sumatriptan 5 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
fluoxetine 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Hypoglycemia 13 100.00 Very High Very High Very High
Hyperglycemia 10 100.00 Very High Very High Very High
Growth Problems 79 99.88 Very High Very High Very High
Obesity 35 99.84 Very High Very High Very High
Hypercalcemia 4 99.84 Very High Very High Very High
Turner's Syndrome 280 99.80 Very High Very High Very High
Panic Disorder 21 99.74 Very High Very High Very High
Hypertension 7 99.70 Very High Very High Very High
Cancer 3 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Growth hormone responses to growth hormone-releasing hormone and clonidine before and after erythropoietin therapy in CAPD patients.
Regulation (responses) of Growth hormone associated with renal failure and clonidine
1) Confidence 0.61 Published 1996 Journal Nephron Section Title Doc Link 8938679 Disease Relevance 0.81 Pain Relevance 0.30
Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children.
Regulation (Effect) of GHRH in plasma associated with hypoglycemia and clonidine
2) Confidence 0.59 Published 1990 Journal Acta Endocrinol. Section Title Doc Link 2106191 Disease Relevance 0.26 Pain Relevance 0.59
Naloxone effects on serum growth hormone and prolactin in man.
Regulation (effects) of growth hormone associated with narcan
3) Confidence 0.52 Published 1979 Journal Psychopharmacology (Berl.) Section Title Doc Link 116298 Disease Relevance 0 Pain Relevance 0.33
Specifically, they suggest involvement of the EOS in the tonic regulation of normal human mood, memory, BP, respirations, and plasma growth hormone and cortisol levels.
Regulation (regulation) of plasma growth hormone in plasma
4) Confidence 0.50 Published 1983 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6303264 Disease Relevance 0 Pain Relevance 0.34
CONCLUSIONS: Naloxone is able to decrease the effect of a maximal dose of GHRH, thus suggesting the existence of an opioid stimulatory tone on GH secretion.


Regulation (effect) of GHRH
5) Confidence 0.45 Published 1998 Journal Horm. Metab. Res. Section Body Doc Link 9503036 Disease Relevance 0 Pain Relevance 0
Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma.
Regulation (effects) of growth hormone in plasma associated with fortral
6) Confidence 0.45 Published 1987 Journal Pharmacol. Toxicol. Section Title Doc Link 3438224 Disease Relevance 0.06 Pain Relevance 0.59
Comparison of GH responses after GHRH with GH output following the alpha 2-agonist clonidine (CLON) revealed a significant positive correlation.
Regulation (responses) of GHRH associated with agonist and clonidine
7) Confidence 0.45 Published 1988 Journal Psychiatry Res Section Abstract Doc Link 3141943 Disease Relevance 0.23 Pain Relevance 0.33
On the other hand, YOH was unable to affect the GH response to GHRH (339.3 +/- 19.1 vs. 518 +/- 172.8 micrograms/l/h).
Regulation (response) of GHRH
8) Confidence 0.45 Published 1990 Journal Endocrinol. Exp. Section Abstract Doc Link 1972919 Disease Relevance 0 Pain Relevance 0.67
Correction of the anemia was accompanied by a clear increase in the area under the curve (AUC) and the area above the baseline (AAB) of GH secretion in response to GHRH stimulation.
Regulation (response) of GHRH associated with anaemia
9) Confidence 0.44 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10024084 Disease Relevance 0.87 Pain Relevance 0.14
However, significant GH responses to TRH or hpGRF were observed when the interval between injections was either 120 or 240 min.
Regulation (responses) of hpGRF
10) Confidence 0.44 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
Conversely, atropine pretreatment significantly (P less than 0.01) blocked the GH response to GHRH challenge, whereas yohimbine did not significantly affect it.
Regulation (response) of GHRH
11) Confidence 0.44 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.49
Their peak GH responses to GHRH (5.45+/-0.78 and 4.99+/-0.86 ng/ml) and clonidine administration (4.21+/-0.32 and 4.15+/-0.27 ng/ml in males and females, respectively) were markedly reduced with respect to control subjects (p<0.01).
Regulation (responses) of GHRH associated with clonidine
12) Confidence 0.44 Published 2003 Journal J. Endocrinol. Invest. Section Abstract Doc Link 14594112 Disease Relevance 0.16 Pain Relevance 0.10
We have investigated the effect of hypothalamo-pituitary disconnection in the rat on the growth hormone (GH) responsiveness to human pancreatic GH-releasing factor (hpGRF).
Spec (investigated) Regulation (effect) of GRF in pituitary
13) Confidence 0.44 Published 1984 Journal Life Sci. Section Abstract Doc Link 6436609 Disease Relevance 0 Pain Relevance 0.09
Comparison of growth hormone responses to human pancreatic growth hormone releasing factor and other pharmacological stimuli in acromegalic patients.
Regulation (responses) of growth hormone
14) Confidence 0.44 Published 1984 Journal Endocrinol. Jpn. Section Title Doc Link 6437801 Disease Relevance 0 Pain Relevance 0.20
Compounds thought to inhibit hypothalamic somatostatin (SRIH) release (pyridostigmine, arginine, galanin, atenolol) consistently improve, though do not normalize, the somatotropin response to GHRH in obesity.
Regulation (response) of GHRH associated with obesity and somatostatin
15) Confidence 0.43 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193871 Disease Relevance 0.57 Pain Relevance 0.19
Influence of naloxone on gastric emptying of solid meals, myoelectrical gastric activity and blood hormone levels in young healthy volunteers.
Regulation (Influence) of blood hormone in blood associated with narcan
16) Confidence 0.43 Published 2002 Journal Neurogastroenterol. Motil. Section Title Doc Link 12358676 Disease Relevance 0 Pain Relevance 0.42
In conclusion, our data show that patients with FM exhibited a marked decrease in spontaneous GH secretion, but normal pituitary responsiveness to exogenously administered GHRH, thus suggesting the existence of an alteration at the hypothalamic level in the neuroendocrine control of GH in these patients.
Regulation (responsiveness) of GHRH in pituitary associated with fibrositis
17) Confidence 0.41 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 0.77 Pain Relevance 0.40
The alpha 2-adrenergic agonist did not affect GH secretion in the anti-GHRH group, whereas immunization against SRIH did not modify the GH response.
Neg (not) Regulation (affect) of anti-GHRH associated with immunization, somatostatin and agonist
18) Confidence 0.39 Published 1994 Journal Endocrinology Section Abstract Doc Link 7905408 Disease Relevance 0.10 Pain Relevance 0.98
The GH-releasing action of ghrelin takes place both directly on pituitary cells and through modulation of GHRH from the hypothalamus; some functional anti-somatostatin action has also been shown.
Regulation (modulation) of GHRH in hypothalamus associated with somatostatin
19) Confidence 0.39 Published 2010 Journal Front Horm Res Section Abstract Doc Link 20616513 Disease Relevance 0 Pain Relevance 0.16
Electrophysiology of human growth hormone secreting tumour cells and its modification by hGRF has been studied using on-cell and Nystatin-perforated whole-cell recording configurations.
Regulation (Electrophysiology) of growth hormone associated with cancer
20) Confidence 0.39 Published 1993 Journal Brain Res. Section Abstract Doc Link 8384513 Disease Relevance 0.17 Pain Relevance 0.11

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