INT2500

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Context Info
Confidence 0.18
First Reported 1979
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 0.60
Pain Relevance 8.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 10
plasma 2
striatum 2
ganglion 2
lobe 2
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 7 99.84 Very High Very High Very High
opioid receptor 6 99.56 Very High Very High Very High
Enkephalin 24 99.54 Very High Very High Very High
Morphine 22 99.44 Very High Very High Very High
Hippocampus 1 99.34 Very High Very High Very High
agonist 16 99.20 Very High Very High Very High
narcan 12 99.16 Very High Very High Very High
Kappa opioid receptor 7 98.56 Very High Very High Very High
antagonist 17 97.80 Very High Very High Very High
Dopamine 49 93.76 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 96.12 Very High Very High Very High
Urological Neuroanatomy 1 90.56 High High
Galactorrhea 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the inhibiting effect of apomorphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (0.5 mg/kg) on the accumulation of DOPA in rats treated with reserpine was weakly counteracted by morphine (10 mg/kg s.c.).
Negative_regulation (effect) of Positive_regulation (accumulation) of DOPA associated with morphine
1) Confidence 0.18 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.27
Since the effects of morphine on the apomorphine-induced inhibition of DOPA accumulation were antagonized by naloxone, we suggest that the effects on striatal DOPA accumulation produced by morphine were mediated via opioid receptors and not directly via DA receptors.
Negative_regulation (inhibition) of Positive_regulation (accumulation) of DOPA associated with narcan, opioid receptor and morphine
2) Confidence 0.18 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.22
The rate of DOPA accumulation in Na+-free media was increased in Halo-treated rats and was decreased in Bromo-treated rats.
Negative_regulation (decreased) of Positive_regulation (accumulation) of DOPA
3) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.27
The basal rate of in vitro DOPA accumulation in the median eminence was increased in Halo-treated rats and was decreased in Bromo-treated rats.
Negative_regulation (decreased) of Positive_regulation (accumulation) of DOPA in median eminence
4) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.39
Acute WIN (8 mg/kg; 1 h) increased DOPA synthesis in cortex (52%), hippocampus (51%), and cerebellum (56%) and decreased DOPA accumulation in striatum (31%).
Negative_regulation (decreased) of Positive_regulation (accumulation) of DOPA in striatum associated with hippocampus
5) Confidence 0.07 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18709357 Disease Relevance 0 Pain Relevance 0.88
Veratridine-stimulated DOPA accumulation is blocked by tetrodotoxin, but not by cholinergic or adrenergic antagonists or by decentralization of the ganglion.
Negative_regulation (blocked) of Positive_regulation (accumulation) of DOPA in ganglion associated with ganglion cysts, tetrodotoxin and antagonist
6) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.36 Pain Relevance 0.15
The rank order of the potencies of enkephalins and their analogs for inhibition of DOPA accumulation in the median eminence was similar to that of their binding capacities for opioid receptors.
Negative_regulation (inhibition) of Positive_regulation (accumulation) of DOPA in median eminence associated with opioid receptor and enkephalin
7) Confidence 0.04 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.67
In contrast, ENKamide decreased neither the rate of depolarization- induced CA2+-dependent DOPA accumulation nor the rate of (Bu)2cAMP- or forskolin-induced DOPA accumulation in the median eminence of normal or haloperidol-treated rats.
Negative_regulation (decreased) of Neg (neither) Positive_regulation (accumulation) of DOPA in median eminence
8) Confidence 0.03 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.62
ENKamide inhibited basal DOPA accumulation even when hypothalamic slices were incubated in Ca2+-free medium to which tetrodotoxin was added or when the median eminence was incubated alone without the remainder of the hypothalamic slice.
Negative_regulation (inhibited) of Positive_regulation (accumulation) of DOPA in median eminence associated with tetrodotoxin
9) Confidence 0.03 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.68
The enkephalin agonist [D-Ala2]Met-enkephalinamide (ENKamide) decreased the rate of basal DOPA accumulation in the median eminence portion of hypothalamic slices from ovariectomized rats at concentrations over 2 microM.
Negative_regulation (decreased) of Positive_regulation (accumulation) of DOPA in median eminence associated with agonist and enkephalin
10) Confidence 0.03 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.49
U-50488 produced a dose- and time-dependent increase in plasma concentrations of alpha-MSH which was accompanied by a decrease in the accumulation of DOPA and in the intermediate lobe.
Negative_regulation (decrease) of Positive_regulation (accumulation) of DOPA in plasma
11) Confidence 0.01 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2177159 Disease Relevance 0 Pain Relevance 0.63
The effects of U-50488 on plasma alpha-MSH concentrations and intermediate-lobe DOPA accumulation were blocked by pretreatment with the selective kappa-opioid receptor antagonist nor-binaltorphimine.
Negative_regulation (blocked) of Positive_regulation (accumulation) of DOPA in lobe associated with antagonist and kappa opioid receptor
12) Confidence 0.01 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2177159 Disease Relevance 0 Pain Relevance 0.64
In vehicle treated rats, suckling caused a significant and selective decrease in DOPA accumulation in the ME. beta-FNA (5 micrograms, i.c.v.) pretreatment significantly increased DOPA accumulation in the ME of pup-deprived and pup-suckled rats. beta-FNA pretreatment also prevented the suckling-induced suppression of DOPA accumulation in the ME.
Negative_regulation (decrease) of Positive_regulation (accumulation) of DOPA
13) Confidence 0.01 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8910807 Disease Relevance 0.09 Pain Relevance 0.67

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