INT250022

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map3k1) cytoplasm (Map3k1)
Map3k1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 81.08 Quite High
cva 1 44.04 Quite Low
Sciatic nerve 9 19.20 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 33 99.84 Very High Very High Very High
Stress 20 94.24 High High
Hyperglycemia 2 86.84 High High
Diabetes Mellitus 54 85.24 High High
Diabetic Cardiomyopathies 2 83.96 Quite High
Injury 10 51.48 Quite High
Cancer 1 45.72 Quite Low
Coronary Heart Disease 3 44.80 Quite Low
Metastasis 2 44.12 Quite Low
Cv General 3 Under Development 1 44.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [22–24].
Regulation (affects) of MAPK kinase kinase
1) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
Yoon et al. [39] postulated that H2O2 induces an increase in apoptosis signal regulating kinase-1 which cause down regulation of antiapoptotic Bcl-2, disruption of the mitochondrial membrane potential and activation of caspase cascade [40].
Regulation (regulating) of kinase-1 associated with apoptosis
2) Confidence 0.01 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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