INT250028

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.48

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Anatomy Link Frequency brain 2 Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 29 100.00 Catecholamine 1 91.00 Substantia nigra 3 82.36 noradrenaline 2 74.64 Serotonin 3 50.00 tolerance 6 22.56 sSRI 4 5.00 antagonist 2 5.00 Central nervous system 1 5.00 fluoxetine 1 5.00

Disease Link Frequency Relevance Heat Fever 5 99.84 Fatigue 24 97.08 Hypothermia 1 83.64 Stress 9 34.52 Pressure And Volume Under Development 1 5.00 Depression 1 5.00 Respiratory Disease 1 5.00 Injury 1 5.00 Heat Stress Disorders 1 5.00 Dyspnea 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nybo et al. [8] however, found that brain uptake of Trp and Tyr as well as brain DA release were not affected by hyperthermia, failing therefore to support the classic "5-HT-central fatigue hypothesis" [37]; and also the involvement of brain DA function in thermoregulation during exercise in the heat.

Neg (not) Regulation (affected) of Localization (release) of Trp in brain associated with dopamine, fatigue and fever

1) Confidence 0.17 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.61 Pain Relevance 0.48

General Comments

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