INT250045

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr143) Golgi apparatus (Gpr143) plasma membrane (Gpr143)
lysosome (Gpr143) signal transducer activity (Gpr143)
Gpr143 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 62 100.00 Very High Very High Very High
Neurotransmitter 4 97.68 Very High Very High Very High
Glutamate receptor 14 94.88 High High
Pyramidal cell 24 83.76 Quite High
Anterior cingulate cortex 128 83.04 Quite High
nMDA receptor 10 54.92 Quite High
IPN 22 50.00 Quite Low
Neuronal excitability 6 28.68 Quite Low
nMDA receptor antagonist 4 18.24 Low Low
Lasting pain 48 9.76 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 62 91.68 High High
Inflammatory Pain 22 50.00 Quite Low
Pain 68 9.76 Low Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the results demonstrate the enhanced presynaptic glutamate release after activation of Ap oa1 by application of octopamine.


Positive_regulation (enhanced) of Positive_regulation (activation) of oa1 associated with glutamate
1) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.40 Pain Relevance 0.45
Taken together, we found that exogenous activation of Ap oa1 facilitates excitatory synaptic transmission via increasing presynaptic glutamate release.
Positive_regulation (increasing) of Positive_regulation (activation) of oa1 associated with glutamate
2) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0 Pain Relevance 0.40

General Comments

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