INT250046

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr143) Golgi apparatus (Gpr143) plasma membrane (Gpr143)
lysosome (Gpr143) signal transducer activity (Gpr143)
Anatomy Link Frequency
neuronal 2
forebrain 2
Gpr143 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 10 99.20 Very High Very High Very High
Anterior cingulate cortex 128 98.52 Very High Very High Very High
Pyramidal cell 24 97.92 Very High Very High Very High
Neuronal excitability 6 97.36 Very High Very High Very High
Neurotransmitter 4 81.56 Quite High
Lasting pain 48 77.24 Quite High
IPN 22 72.08 Quite High
Inflammation 14 67.88 Quite High
Glutamate 62 67.76 Quite High
spinal dorsal horn 2 49.20 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 62 98.48 Very High Very High Very High
Anxiety Disorder 4 93.16 High High
Pain 68 77.24 Quite High
Inflammatory Pain 22 72.08 Quite High
INFLAMMATION 16 67.88 Quite High
Nociception 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterologous expression of Ap oa1 receptor in mice forebrain is not affecting either NMDA or non-NMDA receptor-mediated synaptic transmission, suggesting no endogenous activation of Ap oa1 receptor.
Neg (not) Regulation (affecting) of Gene_expression (expression) of oa1 in forebrain associated with nmda receptor
1) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.23 Pain Relevance 0.27
To examine whether heterologous expression of Ap oa1 affects neuronal and synaptic properties of ACC neurons, we compared the neuronal excitability and basal synaptic transmissions in wild-type (WT) and transgenic mice.
Spec (whether) Regulation (affects) of Gene_expression (expression) of oa1 in neuronal associated with targeted disruption, neuronal excitability and anterior cingulate cortex
2) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.65 Pain Relevance 0.96

General Comments

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