INT250048

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.85
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr143) Golgi apparatus (Gpr143) plasma membrane (Gpr143)
lysosome (Gpr143) signal transducer activity (Gpr143)
Anatomy Link Frequency
joint 1
medial 1
ACC 1
forebrain 1
Gpr143 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 62 100.00 Very High Very High Very High
Glutamate 341 99.70 Very High Very High Very High
Anterior cingulate cortex 704 99.68 Very High Very High Very High
long-term potentiation 88 99.00 Very High Very High Very High
nMDA receptor 55 98.84 Very High Very High Very High
Neurotransmitter 22 97.68 Very High Very High Very High
Glutamate receptor 77 97.60 Very High Very High Very High
Lasting pain 264 95.72 Very High Very High Very High
IPN 121 94.56 High High
Neuronal excitability 33 86.88 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 62 100.00 Very High Very High Very High
Joint Instability 2 100.00 Very High Very High Very High
Pain 378 95.72 Very High Very High Very High
Inflammatory Pain 121 94.56 High High
Targeted Disruption 341 93.28 High High
Injury 86 84.88 Quite High
INFLAMMATION 90 75.60 Quite High
Nociception 22 75.36 Quite High
Drug Dependence 11 68.00 Quite High
Patellar Dislocation 6 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could explain the pre- but not postsynaptic effect by Ap oa1 activation in modulating of synaptic transmission.
Positive_regulation (activation) of oa1
1) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.05 Pain Relevance 0.35
We found that activation of Ap oa1 receptor did not modulate postsynaptic function.
Positive_regulation (activation) of oa1
2) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0 Pain Relevance 0.27
Taken together, we found that exogenous activation of Ap oa1 facilitates excitatory synaptic transmission via increasing presynaptic glutamate release.
Positive_regulation (activation) of oa1 associated with glutamate
3) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0 Pain Relevance 0.39
However, exogenous application of octopamine, which is known to selectively activate Ap oa1 and subsequently increase cAMP level [32,44], significantly enhanced the amplitude of EPSCs.
Positive_regulation (activate) of oa1
4) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.20 Pain Relevance 0.30
Heterologous expression of Ap oa1 receptor in mice forebrain is not affecting either NMDA or non-NMDA receptor-mediated synaptic transmission, suggesting no endogenous activation of Ap oa1 receptor.
Neg (no) Positive_regulation (activation) of oa1 in forebrain associated with nmda receptor
5) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.21 Pain Relevance 0.29
If this is the case, activation of Ap oa1 receptor may facilitate LTP induction in the ACC.
Positive_regulation (activation) of oa1 associated with long-term potentiation and anterior cingulate cortex
6) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.18 Pain Relevance 0.42
Therefore, the results demonstrate the enhanced presynaptic glutamate release after activation of Ap oa1 by application of octopamine.


Positive_regulation (activation) of oa1 associated with glutamate
7) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.40 Pain Relevance 0.45
We found that activation of Ap oa1 receptors in the ACC enhanced presynaptic glutamate release (Figure 7) as well as behavioral responses to chronic pain.
Positive_regulation (activation) of oa1 associated with glutamate, lasting pain and anterior cingulate cortex
8) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.77 Pain Relevance 0.94
We found that activation of Ap oa1 by octopamine enhanced glutamatergic synaptic transmission in the ACC by increasing presynaptic glutamate release in vitro.
Positive_regulation (activation) of oa1 in ACC associated with glutamate and anterior cingulate cortex
9) Confidence 0.29 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2570662 Disease Relevance 0.72 Pain Relevance 0.88
Mechanisms for enhancement of excitatory synaptic transmission by activation of Ap oa1 receptor
Positive_regulation (activation) of oa1
10) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.31 Pain Relevance 0.25
Our results show that activation of Ap oa1 in the ACC enhanced glutamatergic synaptic transmission by increasing presynaptic glutamate release in vitro and enhanced responses to inflammatory pain in vivo by bilateral microinjection of octopamine.
Positive_regulation (activation) of oa1 associated with glutamate, ipn and anterior cingulate cortex
11) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.89 Pain Relevance 0.90
It is therefore unlikely that pre-existing OA or joint instability inadvertently induced during surgery were the causes for repair failure.
Positive_regulation (induced) of OA in joint associated with joint instability and osteoarthritis
12) Confidence 0.03 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 1.13 Pain Relevance 0.38
C57BL/6 mice develop spontaneous OA with ageing32 and they are more susceptible than DBA/1 to OA induced by destabilization of the medial meniscus (DMM)33.
Positive_regulation (induced) of OA in medial associated with osteoarthritis
13) Confidence 0.03 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.99 Pain Relevance 0.29

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