INT250085

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.52
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Coq7) oxidoreductase activity (Coq7) nucleus (Coq7)
molecular_function (Coq7) cellular_component (Coq7)
Anatomy Link Frequency
spike 3
Coq7 (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 222 100.00 Very High Very High Very High
Calcium channel 3 90.04 High High
amygdala 24 86.88 High High
Action potential 9 82.72 Quite High
imagery 18 73.92 Quite High
Pyramidal cell 9 69.68 Quite High
Hippocampus 30 67.52 Quite High
Central nervous system 3 66.68 Quite High
nMDA receptor 12 50.00 Quite Low
antagonist 51 49.52 Quite Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 3 91.64 High High
Anxiety Disorder 141 83.12 Quite High
Shock 3 29.44 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NR2B-NMDARs are required for LTP induced by the spike-timing protocol, but not by the pairing protocol.
spike-timing Neg (not) Positive_regulation (induced) of LTP in spike associated with long-term potentiation
1) Confidence 0.00 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.15 Pain Relevance 0.52
This difference in kinetics of Ca2+ efflux might help explain why NR2B-NMDARs are required for LTP induced by spike-timing protocol but not pairing protocol.
spike-timing Neg (not) Positive_regulation (induced) of LTP in spike associated with long-term potentiation
2) Confidence 0.00 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.21 Pain Relevance 0.19
LTP induced by spike-timing protocol
spike-timing Positive_regulation (induced) of LTP in spike associated with long-term potentiation
3) Confidence 0.00 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.17 Pain Relevance 0.29

General Comments

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