INT250086

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Coq7) oxidoreductase activity (Coq7) nucleus (Coq7)
plasma membrane (Grin2b) molecular_function (Coq7) embryo development (Grin2b)
Anatomy Link Frequency
spike 4
Grin2b (Rattus norvegicus)
Coq7 (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 148 100.00 Very High Very High Very High
Calcium channel 2 91.20 High High
amygdala 16 88.04 High High
imagery 12 75.08 Quite High
Central nervous system 2 67.84 Quite High
nMDA receptor 8 50.00 Quite Low
antagonist 34 49.52 Quite Low
Hippocampus 20 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 2 92.80 High High
Anxiety Disorder 94 83.12 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This difference in kinetics of Ca2+ efflux might help explain why NR2B-NMDARs are required for LTP induced by spike-timing protocol but not pairing protocol.
NR2B-NMDARs Positive_regulation (required) of spike-timing Neg (not) Positive_regulation (induced) of LTP in spike associated with long-term potentiation
1) Confidence 0.00 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.21 Pain Relevance 0.19
NR2B-NMDARs are required for LTP induced by the spike-timing protocol, but not by the pairing protocol.
NR2B-NMDARs Positive_regulation (required) of spike-timing Neg (not) Positive_regulation (induced) of LTP in spike associated with long-term potentiation
2) Confidence 0.00 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.15 Pain Relevance 0.53

General Comments

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