INT25009

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 12 100.00 Very High Very High Very High
Angina 1 74.36 Quite High
cytokine 14 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1 74.36 Quite High
Myocardial Infarction 1 73.60 Quite High
Dysmenorrhea 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Pre-term Labor 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of plasminogen activator inhibitor1 associated with metalloproteinase
1) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of PAI1 associated with metalloproteinase
2) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Because t-PA antigen levels and PAI-1 activity were highest in the morning, the variation in t-PA activity was probably not due to decreased secretion of t-PA but instead to changes in the secretion of PAI-1.
Regulation (changes) of Localization (secretion) of PAI-1
3) Confidence 0.12 Published 1989 Journal Circulation Section Abstract Doc Link 2491971 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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