INT2501

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Context Info
Confidence 0.19
First Reported 1979
Last Reported 1996
Negated 3
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 2.38
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 10
ganglion 6
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 21 99.74 Very High Very High Very High
narcan 12 99.54 Very High Very High Very High
tetrodotoxin 16 99.40 Very High Very High Very High
agonist 10 98.86 Very High Very High Very High
Morphine 22 98.68 Very High Very High Very High
adenocard 9 96.76 Very High Very High Very High
Dopamine 76 93.68 High High
Enkephalin 6 92.16 High High
opioid receptor 3 80.88 Quite High
Opioid 4 77.72 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 99.40 Very High Very High Very High
Urological Neuroanatomy 1 86.56 High High
Galactorrhea 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone did not significantly change the accumulation of DOPA after apomorphine or after haloperidol.
Neg (not) Positive_regulation (change) of Positive_regulation (accumulation) of DOPA associated with narcan
1) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.15
The DA agonist apomorphine decreased and the DA antagonist haloperidol increased DOPA accumulation.
Positive_regulation (increased) of Positive_regulation (accumulation) of DOPA associated with antagonist and agonist
2) Confidence 0.19 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.10
Furthermore, the stimulation of DOPA accumulation in the median eminence induced by db-cAMP was additive with that induced by high potassium depolarization, which was Ca2+ -dependent.
Positive_regulation (stimulation) of Positive_regulation (accumulation) of DOPA in median eminence
3) Confidence 0.16 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.35
Addition of dibutyryl cAMP (db-cAMP) into medium caused an increase in the rate of DOPA accumulation in the median eminence in a dose- and time-dependent manner. 8-Bromo-cAMP also increased the rate of DOPA accumulation in the median eminence and cAMP was less effective than db-cAMP whereas neither adenosine nor sodium butyrate altered the rate of DOPA accumulation.
Positive_regulation (increase) of Positive_regulation (accumulation) of DOPA in median eminence associated with adenocard
4) Confidence 0.16 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.28
Addition of dibutyryl cAMP (db-cAMP) into medium caused an increase in the rate of DOPA accumulation in the median eminence in a dose- and time-dependent manner. 8-Bromo-cAMP also increased the rate of DOPA accumulation in the median eminence and cAMP was less effective than db-cAMP whereas neither adenosine nor sodium butyrate altered the rate of DOPA accumulation.
Positive_regulation (increased) of Positive_regulation (accumulation) of DOPA in median eminence associated with adenocard
5) Confidence 0.16 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.27
On the other hand, neither Halo nor Bromo treatment altered the increase in DOPA accumulation induced by (Bu)2cAMP or forskolin.
Positive_regulation (induced) of Positive_regulation (accumulation) of DOPA
6) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.19
This difference in DOPA accumulation was due to the changes in PRL secretion after Halo and Bromo treatments, since hypophysectomy abolished it.
Positive_regulation (due) of Positive_regulation (accumulation) of DOPA
7) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.34
Incubation of hypothalamic slices in Na+-free media to increase the intracellular concentration of Ca2+ through inhibition of Na+-Ca2+ exchange caused an increase in DOPA accumulation.
Positive_regulation (increase) of Positive_regulation (accumulation) of DOPA
8) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.32
Incubation of hypothalamic slices in Na+-free media to increase the intracellular concentration of Ca2+ through inhibition of Na+-Ca2+ exchange caused an increase in DOPA accumulation.
Positive_regulation (caused) of Positive_regulation (accumulation) of DOPA
9) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.32
On the other hand, neither Halo nor Bromo treatment altered the increase in DOPA accumulation induced by (Bu)2cAMP or forskolin.
Positive_regulation (increase) of Positive_regulation (accumulation) of DOPA
10) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.19
The basal rate of in vitro DOPA accumulation in the median eminence was increased in Halo-treated rats and was decreased in Bromo-treated rats.
Positive_regulation (increased) of Positive_regulation (accumulation) of DOPA in median eminence
11) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.39
The rate of DOPA accumulation in Na+-free media was increased in Halo-treated rats and was decreased in Bromo-treated rats.
Positive_regulation (increased) of Positive_regulation (accumulation) of DOPA
12) Confidence 0.12 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.27
Incubation of the ganglion with veratridine (50 microM) causes a 10-fold increase in the rate of DOPA accumulation.
Positive_regulation (causes) of Positive_regulation (accumulation) of DOPA in ganglion associated with ganglion cysts
13) Confidence 0.07 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.36 Pain Relevance 0.14
The cyclic nucleotide 8-bromo cyclic GMP does not increase DOPA accumulation, and 8-bromo cyclic AMP causes only a 2-fold increase in DOPA accumulation, which is additive with the effect of veratridine.
Neg (not) Positive_regulation (increase) of Neg (not) Positive_regulation (accumulation) of DOPA
14) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.35 Pain Relevance 0.14
Veratridine-stimulated DOPA accumulation is blocked by tetrodotoxin, but not by cholinergic or adrenergic antagonists or by decentralization of the ganglion.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of DOPA in ganglion associated with ganglion cysts, tetrodotoxin and antagonist
15) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.36 Pain Relevance 0.15
Incubation of the ganglion with veratridine (50 microM) causes a 10-fold increase in the rate of DOPA accumulation.
Positive_regulation (increase) of Positive_regulation (accumulation) of DOPA in ganglion associated with ganglion cysts
16) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.36 Pain Relevance 0.14
The cyclic nucleotide 8-bromo cyclic GMP does not increase DOPA accumulation, and 8-bromo cyclic AMP causes only a 2-fold increase in DOPA accumulation, which is additive with the effect of veratridine.
Positive_regulation (increase) of Positive_regulation (accumulation) of DOPA
17) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.34 Pain Relevance 0.14
In contrast, ENKamide decreased neither the rate of depolarization- induced CA2+-dependent DOPA accumulation nor the rate of (Bu)2cAMP- or forskolin-induced DOPA accumulation in the median eminence of normal or haloperidol-treated rats.
Neg (neither) Positive_regulation (induced) of Neg (neither) Positive_regulation (accumulation) of DOPA in median eminence
18) Confidence 0.04 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.62
In vehicle treated rats, suckling caused a significant and selective decrease in DOPA accumulation in the ME. beta-FNA (5 micrograms, i.c.v.) pretreatment significantly increased DOPA accumulation in the ME of pup-deprived and pup-suckled rats. beta-FNA pretreatment also prevented the suckling-induced suppression of DOPA accumulation in the ME.
Positive_regulation (increased) of Positive_regulation (accumulation) of DOPA
19) Confidence 0.01 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8910807 Disease Relevance 0.09 Pain Relevance 0.65

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