INT250144

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.77
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD274) signal transduction (CD274) plasma membrane (CD274)
Anatomy Link Frequency
CD86 4
PDL-1 4
plasma 1
NK cells 1
CD274 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 90 90.04 High High
dexamethasone 2 85.84 High High
Inflammation 323 84.92 Quite High
agonist 23 80.24 Quite High
chemokine 63 69.76 Quite High
rheumatoid arthritis 9 64.16 Quite High
GABAergic 1 62.04 Quite High
cytokine 34 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
COX2 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 810 99.00 Very High Very High Very High
Pancreatitis 90 90.04 High High
Cancer 393 85.76 High High
INFLAMMATION 325 84.92 Quite High
Breast Cancer 37 80.32 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 36 78.12 Quite High
Hepatitis C Virus Infection 18 76.16 Quite High
Infection 10 71.48 Quite High
Repression 17 69.56 Quite High
Rheumatoid Arthritis 9 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Especially, considering the fact that the PDL-1 and B7H3 levels were increased, providing more factors that impair the ability of DCs to activate T cell responses.
Positive_regulation (increased) of PDL-1 in PDL-1
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.24 Pain Relevance 0.23
-mediated induction of the class B genes IL6 (interleukin-6), CD274 (B7-H1) and CLDN1 (claudin 1), which was clearly detectable 6?
Positive_regulation (ted induc) of CD274
2) Confidence 0.34 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.13 Pain Relevance 0.08
The TLR9 ligation on PDCs induced a mature phenotype with upregulation of CD40, CD83, CD86, CCR7, PDL-1, ICOSL and CCR5 and decreased B7H3 and DCIR (Figure 9).
Positive_regulation (upregulation) of PDL-1 in PDL-1
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.35 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Spec (clear) Positive_regulation (activation) of PDL-1 in CD86
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (levels) of PDL-1 in CD86
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.62 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (increased) of PDL-1 in CD86
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.62 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (enhanced) of PDL-1 in CD86
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.61 Pain Relevance 0.03
The levels of PDL-1 and B7H3 were increased on MDCs pre surgery (median 245, median 5.1) and post surgery (median 252, median 5.2) compared to controls (median 164, median 3.3).
Positive_regulation (increased) of PDL-1 in PDL-1
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.54 Pain Relevance 0
The treatment of blood DCs purified from healthy donors with plasma from PDAC patients or CXCL8 and PGE2 gave similar effect, with significantly enhanced PDL-1 levels.
Positive_regulation (enhanced) of PDL-1 in plasma associated with adenocarcinoma
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.61 Pain Relevance 0.06
The upregulation of PDL-1 and down modulation of ICOSL fits the profile of activated DCs, albeit not a complete activation as they do not reach the levels on fully mature DC.
Positive_regulation (upregulation) of PDL-1 in PDL-1
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.34 Pain Relevance 0.09
Moreover, it indicated that NK cells may contribute to differentiation and resistance of hMSCs by increased induction of key resistance factors such as B7H1.


Positive_regulation (induction) of B7H1 in NK cells
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0.04
At 48 h postplating, the nestin+ cell number increased on PDL/laminin by approximately 4-fold and on Matrigel by about 3-fold.
Positive_regulation (increased) of PDL
12) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0.03

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