INT250153

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.83
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PRNP, IKBKG) nucleus (PRNP, IKBKG) Golgi apparatus (PRNP)
endoplasmic reticulum (PRNP) signal transducer activity (IKBKG) cytosol (IKBKG)
PRNP (Homo sapiens)
IKBKG (Homo sapiens)
IKBKG - P102L (1)
Pain Link Frequency Relevance Heat
cerebral cortex 3 63.28 Quite High
iatrogenic 3 20.16 Low Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Electroencephalography 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 156 100.00 Very High Very High Very High
Scrapie 9 99.92 Very High Very High Very High
Dementia 15 90.40 High High
Syndrome 30 79.52 Quite High
Ataxia 18 73.76 Quite High
Amyloid Plaque 6 66.32 Quite High
Cognitive Disorder 96 59.80 Quite High
Gliosis 3 47.12 Quite Low
Neurodegenerative Disease 12 42.36 Quite Low
Cerebellar Diseases 9 35.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IPD is associated with point mutations in the human prion protein gene (PRNP), premature stop codon mutations and alteration in the number of octapeptide repeat insertions (OPRI) in the unstructured region of the N-terminal domain (Mead, 2006).
prion protein gene Binding (associated) of IPD associated with creutzfeldt jakob disease
1) Confidence 0.09 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 1.18 Pain Relevance 0.03
IPD is associated with point mutations in the human prion protein gene (PRNP), premature stop codon mutations and alteration in the number of octapeptide repeat insertions (OPRI) in the unstructured region of the N-terminal domain (Mead, 2006).
PRNP Binding (associated) of IPD associated with creutzfeldt jakob disease
2) Confidence 0.09 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 1.18 Pain Relevance 0.03
Four of the seven P102L IPD patients examined in this study were negative for prion protein (scrapie isoform), which most probably relates to sampling issues and the differing density of PrP deposition in tissue samples both within and between patients.
prion protein Binding (negative) of IPD (P102L) associated with creutzfeldt jakob disease and scrapie
3) Confidence 0.08 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.48 Pain Relevance 0

General Comments

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