INT250157

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.54
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSS) small molecule metabolic process (GSS) aging (GSS)
ligase activity (GSS) cellular amino acid metabolic process (GSS)
GSS (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
cerebral cortex 1 94.68 High High
Potency 13 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 10 100.00 Very High Very High Very High
Amyloid Plaque 2 93.16 High High
Dementia 5 90.08 High High
Ataxia 6 89.52 High High
Creutzfeldt Jakob Disease 52 85.84 High High
Neurodegenerative Disease 4 83.12 Quite High
Hepatocellular Cancer 4 69.96 Quite High
Toxicity 181 59.12 Quite High
Disease 19 12.72 Low Low
Cognitive Disorder 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is considerable heterogeneity, however, even between first-degree relatives, which has led to delayed diagnosis in those not presenting with typical GSS.
Neg (not) Gene_expression (presenting) of GSS associated with syndrome
1) Confidence 0.22 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 1.35 Pain Relevance 0.05
The enzymes involved in the synthesis of GSH (glutamate-cysteine ligase and GSH synthetase) are also present and can be up regulated by exogenous chemicals [15].
Gene_expression (synthesis) of GSH synthetase associated with glutamate
2) Confidence 0.08 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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