INT250171

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.95
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 103 99.84 Very High Very High Very High
Mechanotransduction 6 99.84 Very High Very High Very High
chemokine 22 92.80 High High
cytokine 59 92.36 High High
Inflammatory response 23 81.36 Quite High
ischemia 14 50.00 Quite Low
agonist 3 32.72 Quite Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 120 99.84 Very High Very High Very High
Adhesions 8 97.36 Very High Very High Very High
Lymphatic System Cancer 1 94.44 High High
Leukemia 1 94.08 High High
Shock 1 84.52 Quite High
Injury 203 83.72 Quite High
Stress 16 81.28 Quite High
Repression 1 74.56 Quite High
Cytomegalovirus Infection 14 62.76 Quite High
Infection 6 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that the MyD88-dependent effects we observe are not directly related to mechanotransduction signaling pathways, but rather to transcript instability in the absence of MyD88 expression, as described for IFN-?
Neg (not) Localization (related) of MyD88 associated with mechanotransduction
1) Confidence 0.72 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.44 Pain Relevance 0.26
Except for TLR3, all TLRs control these innate immune responses through a conserved downstream signaling pathway, starting with the translocation of the adapter molecule MyD88 (myeloid differentiation factor 88) that ultimately leads to the early activation of NF?
Localization (translocation) of MyD88
2) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.38 Pain Relevance 0.16
B signaling in inflammatory cells, Myd88 and Tollip were selected for further analysis and validated using qRT-PCR (Fig. 6C).
Localization (selected) of Myd88 associated with inflammation
3) Confidence 0.58 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.86 Pain Relevance 0.12
Upon stimulation with LPS or TNF, a splice-variant of MyD88, MyD88s, can be induced which prevents activation of NF?
Localization (variant) of MyD88
4) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.13 Pain Relevance 0.17
Upon stimulation with LPS or TNF, a splice-variant of MyD88, MyD88s, can be induced which prevents activation of NF?
Localization (variant) of MyD88s
5) Confidence 0.54 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.13 Pain Relevance 0.17

General Comments

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