INT2502

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 1979
Last Reported 1992
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.92
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 4
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 3 100.00 Very High Very High Very High
Morphine 11 99.84 Very High Very High Very High
narcan 6 99.56 Very High Very High Very High
tetrodotoxin 5 99.12 Very High Very High Very High
opioid receptor 1 98.76 Very High Very High Very High
antagonist 8 98.56 Very High Very High Very High
cerebral cortex 2 97.92 Very High Very High Very High
agonist 4 97.18 Very High Very High Very High
Dopamine 8 87.28 High High
noradrenaline 3 77.20 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 90.60 High High
Decapitation 1 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the effects of morphine on the apomorphine-induced inhibition of DOPA accumulation were antagonized by naloxone, we suggest that the effects on striatal DOPA accumulation produced by morphine were mediated via opioid receptors and not directly via DA receptors.
Regulation (effects) of Gene_expression (produced) of DOPA associated with narcan, opioid receptor and morphine
1) Confidence 0.11 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 456411 Disease Relevance 0 Pain Relevance 1.19
On the other hand, tetrodotoxin (2 microM), a Na+ channel blocker, did not change the basal and K+-induced DOPA synthesis in the median eminence whereas it completely inhibited the veratridine-induced DOPA synthesis.
Neg (not) Regulation (change) of Gene_expression (synthesis) of DOPA in median eminence associated with tetrodotoxin
2) Confidence 0.06 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.24
Removal of Ca2+ and addition of EGTA (1 mM) into the medium did not influence basal DOPA synthesis in the median eminence but blocked the K+- and veratridine-induced DOPA synthesis.
Neg (not) Regulation (influence) of Gene_expression (synthesis) of DOPA in median eminence
3) Confidence 0.06 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.22
However, other agonists (oxymetazoline, azepexole, tramazoline, methoxamine) and antagonists (tolazoline, dihydroergotamine, phenoxybenzamine, propranolol) did not modify the synthesis of DOPA.
Neg (not) Regulation (modify) of Gene_expression (synthesis) of DOPA associated with antagonist and agonist
4) Confidence 0.03 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.07 Pain Relevance 0.65
Low-Na+ medium also increased the incorporation of 32Pi into tyrosine hydroxylase; the dependence of tyrosine hydroxylase phosphorylation on the Na+ concentration resembled that of DOPA synthesis.
Regulation (dependence) of Gene_expression (synthesis) of DOPA associated with addiction
5) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.25 Pain Relevance 0.16
The stimulatory effects of low-Na+ medium on DOPA production and on tyrosine hydroxylase activity in vitro were dependent on extra-cellular Ca2+.
Regulation (effects) of Gene_expression (production) of DOPA
6) Confidence 0.01 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.17
The stimulatory effects of low-Na+ medium on DOPA production and on tyrosine hydroxylase activity in vitro were dependent on extra-cellular Ca2+.
Regulation (dependent) of Gene_expression (production) of DOPA
7) Confidence 0.01 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox