INT25020

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Context Info
Confidence 0.76
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.97
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
uterine 4
glial cells 1
neurons 1
platelet 1
stomach fundus 1
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 39 99.58 Very High Very High Very High
Paracetamol 3 99.36 Very High Very High Very High
Inflammation 57 99.32 Very High Very High Very High
dexamethasone 41 93.44 High High
cytokine 48 93.00 High High
abdominal pain 1 84.44 Quite High
Inflammatory response 12 83.72 Quite High
Dismenorea 12 64.88 Quite High
tetrodotoxin 1 60.72 Quite High
cINOD 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Obstructive Jaundice 37 99.86 Very High Very High Very High
Pancreatitis 79 99.72 Very High Very High Very High
Inflammatory Bowel Disease 3 99.70 Very High Very High Very High
INFLAMMATION 110 99.38 Very High Very High Very High
Hepatotoxicity 2 98.48 Very High Very High Very High
Apoptosis 63 97.80 Very High Very High Very High
Injury 16 93.08 High High
Disease 38 89.76 High High
Death 8 86.16 High High
Abdominal Pain 1 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to determine whether uterine sensitivity to PCB stimulation is dependent on PLA2 expression, comparing rat uterine PLA2 expression in Gestational Day (gd) 10 versus gd20.
Gene_expression (expression) of PLA2 in uterine
1) Confidence 0.76 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0.05 Pain Relevance 0.05
The purpose of the present study was to determine whether uterine sensitivity to PCB stimulation is dependent on PLA2 expression, comparing rat uterine PLA2 expression in Gestational Day (gd) 10 versus gd20.
Gene_expression (expression) of PLA2 in uterine
2) Confidence 0.76 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0.05 Pain Relevance 0.05
Western blot analysis revealed a significant increase in the expression of calcium-dependent PLA2G2A and a 50-kDa protein immunoreactive to calcium-independent PLA2G6 antibody in gd20 compared to gd10 rat uterine tissue.
Gene_expression (expression) of PLA2G2A in uterine
3) Confidence 0.76 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0.06 Pain Relevance 0.06
There is limited information regarding the expression pattern and activity of uterine PLA2 enzymes during pregnancy.
Gene_expression (expression) of PLA2 in uterine
4) Confidence 0.58 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0 Pain Relevance 0
Phospholipase A2 (PLA2) from the venom of the snake Trimeresurus flavoviridis produced an increase in resting tension of isolated strips of rat stomach fundus.
Gene_expression (produced) of PLA2 in stomach fundus
5) Confidence 0.45 Published 1989 Journal Life Sci. Section Abstract Doc Link 2492627 Disease Relevance 0 Pain Relevance 0.06
The pathophysiology of inflammatory bowel disease (IBD) involves the production of diverse lipid mediators, namely eicosanoids, lysophospholipids, and platelet-activating factor, in which phospholipase A2 (PLA2) is the key enzyme.
Gene_expression (production) of PLA2 in platelet associated with inflammatory bowel disease and inflammation
6) Confidence 0.31 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12724134 Disease Relevance 0.49 Pain Relevance 0.09
treated group was positively correlated with PLA2 and the expression of amylase, NO, and
Gene_expression (expression) of PLA2
7) Confidence 0.28 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.22 Pain Relevance 0.29
In our previous reports, we have detected the serum contents of some inflammatory mediators in SAP and OJ rats (including endotoxin, PLA2, and TNF-?)
Gene_expression (including) of PLA2 associated with inflammatory mediators, pancreatitis and obstructive jaundice
8) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.51 Pain Relevance 0.23
Compared to the control group, the compression group showed a significant decrease in the number of the HRP-labeled cells and a significant increase in levels of PGE2 and PLA2, in the expression of VEGF protein, and in the number of apoptotic DRG neurons.
Gene_expression (levels) of PLA2 in neurons associated with apoptosis
9) Confidence 0.09 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.38 Pain Relevance 0.04
Inhibitors of PLA2, cyclooxygenase and thromboxane synthetase injected i.p. 7 h after paracetamol prevented hepatotoxicity as measured by SGPT activity but did not prevent an increase in glycogen phosphorylase "a" activity.
Gene_expression (injected) of PLA2 associated with paracetamol and hepatotoxicity
10) Confidence 0.07 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.43 Pain Relevance 0.27
COX-2, an enzyme in the PLA-2 cascade, involved in the arachidonic acid metabolic pathways for the synthesis of prostaglandins, is yet another enzyme that is expressed along with other inflammatory mediators in these glial cells [6].
Gene_expression (expressed) of PLA-2 in glial cells associated with inflammatory mediators
11) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.77 Pain Relevance 0.33

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