INT25021

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Context Info
Confidence 0.68
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.83
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
neurons 4
uterine 2
stomach fundus 2
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2 88.64 High High
Dismenorea 3 64.88 Quite High
tetrodotoxin 1 61.68 Quite High
Sciatica 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 6 97.68 Very High Very High Very High
INFLAMMATION 2 88.64 High High
Injury 6 75.00 Quite High
Dysmenorrhea 3 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis revealed a significant increase in the expression of calcium-dependent PLA2G2A and a 50-kDa protein immunoreactive to calcium-independent PLA2G6 antibody in gd20 compared to gd10 rat uterine tissue.
Positive_regulation (increase) of Gene_expression (expression) of PLA2G2A in uterine
1) Confidence 0.68 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16436530 Disease Relevance 0.06 Pain Relevance 0.06
Phospholipase A2 (PLA2) from the venom of the snake Trimeresurus flavoviridis produced an increase in resting tension of isolated strips of rat stomach fundus.
Positive_regulation (increase) of Gene_expression (produced) of PLA2 in stomach fundus
2) Confidence 0.29 Published 1989 Journal Life Sci. Section Abstract Doc Link 2492627 Disease Relevance 0 Pain Relevance 0.06
Compared to the control group, the compression group showed a significant decrease in the number of the HRP-labeled cells and a significant increase in levels of PGE2 and PLA2, in the expression of VEGF protein, and in the number of apoptotic DRG neurons.
Positive_regulation (levels) of Gene_expression (levels) of PLA2 in neurons associated with apoptosis
3) Confidence 0.06 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.38 Pain Relevance 0.04
Compared to the control group, the compression group showed a significant decrease in the number of the HRP-labeled cells and a significant increase in levels of PGE2 and PLA2, in the expression of VEGF protein, and in the number of apoptotic DRG neurons.
Positive_regulation (increase) of Gene_expression (levels) of PLA2 in neurons associated with apoptosis
4) Confidence 0.06 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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