INT25022

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 66
Total Number 67
Disease Relevance 22.83
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PAEP) nucleolus (PAEP) nucleus (PAEP)
Anatomy Link Frequency
muscle 4
intestinal cell 1
liver 1
bowel 1
inferior 1
PAEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 42 99.76 Very High Very High Very High
Opioid 4 99.16 Very High Very High Very High
IPN 16 98.94 Very High Very High Very High
Pain 33 98.88 Very High Very High Very High
abdominal pain 21 98.76 Very High Very High Very High
Paracetamol 8 98.62 Very High Very High Very High
headache 15 98.12 Very High Very High Very High
anesthesia 15 97.60 Very High Very High Very High
Antinociceptive 4 96.60 Very High Very High Very High
fibrosis 57 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 91 100.00 Very High Very High Very High
Malignant Neoplastic Disease 23 100.00 Very High Very High Very High
Eosinophilic Granuloma 5 100.00 Very High Very High Very High
Reprotox - General 2 2 100.00 Very High Very High Very High
Urticaria 14 99.60 Very High Very High Very High
Pneumothorax 2 99.36 Very High Very High Very High
Injury 27 99.28 Very High Very High Very High
Disease 202 99.24 Very High Very High Very High
Diarrhoea 10 99.16 Very High Very High Very High
Chronic Hepatitis 94 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that PEG conjugation to biphalin retains opioid-mediated effects observed with biphalin and is a valuable tool for eliciting potent, sustained analgesia via parenteral routes of administration.
PEG Binding (conjugation) of associated with opioid and analgesia
1) Confidence 0.42 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12820142 Disease Relevance 0 Pain Relevance 0.68
And the binding model of PEG with looser IP800 micelles dramatically depends on the molecular weight and concentration of PEG: PEG with lower molecular weight (MW < or = 2000 Da) inserts to the interface of the hydrophilic corona and hydrophobic core of IP800 micelles; PEG with higher molecular weight (MW > 2000 Da) binds to the surface of IP800 micelles, and one long PEG chain (6000 < MW < or = 20000 Da) wraps several IP800 micelles.
PEG Binding (binds) of
2) Confidence 0.39 Published 2010 Journal J Phys Chem B Section Abstract Doc Link 20178332 Disease Relevance 0.06 Pain Relevance 0.12
The PEG can be easily implemented at the time of diagnosis by head and neck surgeons in patients suffering from massive tumor-associated weight loss, when definitive or adjuvant radiochemotherapy is anticipated, or prior to tumor surgery likely to be followed by prolonged significant dysphagia and protracted swallowing rehabilitation.
PEG Binding (implemented) of in neck associated with weight loss, cancer and dysphagia
3) Confidence 0.32 Published 2010 Journal HNO Section Abstract Doc Link 20336266 Disease Relevance 0.69 Pain Relevance 0.15
The baseline data collected were name, personal identity number, age, sex, indication for PEG, comorbidities, and tobacco smoking habits.
PEG Binding (indication) of associated with nicotine addiction
4) Confidence 0.32 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2896486 Disease Relevance 0.65 Pain Relevance 0.17
PEG can, however, be associated with serious complications and death.
PEG Binding (associated) of associated with death
5) Confidence 0.31 Published 1989 Journal Am Surg Section Abstract Doc Link 2492784 Disease Relevance 0.47 Pain Relevance 0.07
PEG is associated with improved nutrition and should be inserted early.
PEG Binding (associated) of
6) Confidence 0.31 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 16324086 Disease Relevance 0.56 Pain Relevance 0.07
PEG is associated with an increase in bowel movement frequency when compared with placebo.
PEG Binding (associated) of in bowel
7) Confidence 0.31 Published 2004 Journal Lakartidningen Section Abstract Doc Link 15446695 Disease Relevance 0.55 Pain Relevance 0.12
We experienced anesthetic management for a patient with PEG associated with bilateral pneumothorax.
PEG Binding (associated) of associated with eosinophilic granuloma and pneumothorax
8) Confidence 0.31 Published 1997 Journal Masui Section Abstract Doc Link 9404132 Disease Relevance 0.53 Pain Relevance 0.48
Patients were given an information folder that contained a description of what had been done during the procedure, the brand name of the PEG catheter, instructions on how to perform daily care of the catheter and the wound site, solutions to common problems associated with PEG, general nutritional advice, and a telephone number for the outpatient surgical clinic and a dietitian for contact whenever advice about the PEG device or nutrition was needed.


PEG Binding (associated) of associated with injury
9) Confidence 0.31 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2896486 Disease Relevance 0.35 Pain Relevance 0.13
The FTIR spectroscopic studies showed the stability of rofecoxib and absence of well-defined rofecoxib-PEG 4000 interaction.
PEG Binding (interaction) of
10) Confidence 0.31 Published 2005 Journal Pharm Dev Technol Section Abstract Doc Link 16370176 Disease Relevance 0.06 Pain Relevance 0.06
Randomized controlled trials comparing the incidence of PEP associated with high- and low-osmolality contrast media (HOCM, LOCM) were considered.
PEP Binding (associated) of associated with pancreatitis
11) Confidence 0.30 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15139506 Disease Relevance 0.81 Pain Relevance 0.09
During therapy, none of the children complained of clinical symptoms associated with PEG, such as urticaria, diarrhea, abdominal pain, headache, dizziness, numbness, seizure, or change of consciousness.
PEG Binding (associated) of associated with urticaria, hypesthesia, abdominal pain, convulsion, diarrhoea, dizziness and headache
12) Confidence 0.30 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004485 Disease Relevance 1.29 Pain Relevance 0.35
And the binding model of PEG with looser IP800 micelles dramatically depends on the molecular weight and concentration of PEG: PEG with lower molecular weight (MW < or = 2000 Da) inserts to the interface of the hydrophilic corona and hydrophobic core of IP800 micelles; PEG with higher molecular weight (MW > 2000 Da) binds to the surface of IP800 micelles, and one long PEG chain (6000 < MW < or = 20000 Da) wraps several IP800 micelles.
PEG Binding (inserts) of
13) Confidence 0.30 Published 2010 Journal J Phys Chem B Section Abstract Doc Link 20178332 Disease Relevance 0.07 Pain Relevance 0.14
And the binding model of PEG with looser IP800 micelles dramatically depends on the molecular weight and concentration of PEG: PEG with lower molecular weight (MW < or = 2000 Da) inserts to the interface of the hydrophilic corona and hydrophobic core of IP800 micelles; PEG with higher molecular weight (MW > 2000 Da) binds to the surface of IP800 micelles, and one long PEG chain (6000 < MW < or = 20000 Da) wraps several IP800 micelles.
PEG Binding (model) of
14) Confidence 0.30 Published 2010 Journal J Phys Chem B Section Abstract Doc Link 20178332 Disease Relevance 0.07 Pain Relevance 0.15
And the binding model of PEG with looser IP800 micelles dramatically depends on the molecular weight and concentration of PEG: PEG with lower molecular weight (MW < or = 2000 Da) inserts to the interface of the hydrophilic corona and hydrophobic core of IP800 micelles; PEG with higher molecular weight (MW > 2000 Da) binds to the surface of IP800 micelles, and one long PEG chain (6000 < MW < or = 20000 Da) wraps several IP800 micelles.
PEG Binding (binding) of
15) Confidence 0.30 Published 2010 Journal J Phys Chem B Section Abstract Doc Link 20178332 Disease Relevance 0.07 Pain Relevance 0.15
Primers for Glycodelin, MMP7, Plexin B1 and GAPDH were used.
Glycodelin Binding (Primers) of
16) Confidence 0.30 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
A sample size of 82 subjects would enable us to detect a correlation coefficient of 0.35 or greater between PEP and %FEV1 values with 90% (?
PEP Binding (detect) of
17) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2855526 Disease Relevance 0.13 Pain Relevance 0
First, a logistic regression model using generalized estimating equations to account for repeated measures on a subject was used to assess the relationship between PEP and accessory muscle use, adjusting for time and any interaction it may have with changes in PEP.
PEP Binding (interaction) of in muscle
18) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2855526 Disease Relevance 0.05 Pain Relevance 0
PEP correlates with airway resistance at baseline and is associated with accessory muscle use at baseline and at 2 and 4 hours after initiation of treatment.
PEP Binding (associated) of in muscle
19) Confidence 0.28 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2855526 Disease Relevance 0.27 Pain Relevance 0.03
PEP was associated with accessory muscle use (OR 1.16, 95% CI, 1.11 to 1.21, P < 0.0001).


PEP Binding (associated) of in muscle
20) Confidence 0.28 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2855526 Disease Relevance 0.32 Pain Relevance 0.04

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