INT250247

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FCGR3A, AQP4) transport (AQP4) extracellular region (FCGR3A)
transmembrane transport (AQP4) cytoplasm (AQP4)
Anatomy Link Frequency
nodes 1
FCGR3A (Homo sapiens)
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 54 97.36 Very High Very High Very High
Inflammation 7 88.88 High High
Central nervous system 21 88.36 High High
Demyelination 2 82.56 Quite High
Glutamate receptor 4 77.48 Quite High
Spinal cord 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
excitatory amino acid 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 87 99.84 Very High Very High Very High
Toxicity 5 95.44 Very High Very High Very High
Demyelinating Disease 15 89.84 High High
INFLAMMATION 8 88.88 High High
Neurodegenerative Disease 3 70.32 Quite High
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Disease Progression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that compromise of EAAT2 function through IgG-induced loss of AQP4 in NMO lesions might increase the extracellular concentration of glutamate in AQP4-rich regions critical to oligodendroglial and neuronal viability at nodes of Ranvier and perisynaptic regions (6).
IgG Negative_regulation (loss) of AQP4 in nodes associated with neuromyelitis optica and glutamate
1) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.87 Pain Relevance 0.62

General Comments

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